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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019030840
pages 561-570

Antioxidant and Anti-Aging Activities of Ethyl Acetate Extract of the Coral Tooth Mushroom, Hericium coralloides (Agaricomycetes)

Jinxiu Zhang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Jing Zhang
Hebei Food Inspection and Research Institute, Shijiazhuang, 050091, People's Republic of China
Liqiang Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Xiaoxi Shui
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li-an Wang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Yuefeng Wu
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China


The in vitro antioxidant effects of petroleum ether, ethyl acetate, and ethanol extracts isolated from Hericium coralloides were investigated. Overall, the ethyl acetate extract of H. coralloides (HcEAE) showed better antioxidant activity in vitro than the petroleum ether and ethanol extracts (HcPEE and HcETE, respectively) of H. coralloides. A comprehensive investigation of the antioxidant activity of the HcEAE in vitro indicated that it possessed superior antioxidant activity, with half maximal inhibitory concentration (IC50) values of 0.93, 1.84, 1.59, and 0.6 mg/mL against DPPH, hydroxyl, ABTS+, and superoxide (O2- ) radicals, respectively. To assess in vivo antioxidant activity, three different doses of HcEAE were orally administered in a D-galactose–induced aged mouse model. Administration of HcEAE significantly increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and lowered the levels of malondialdehyde (MDA) in brains and sera of mice in a dose-dependent manner. A histopathology assessment indicated that the HcEAE could ameliorate the anile condition of the model mice. These results suggest that the HcEAE has potent antioxidant activity and could minimize the occurrence of age-associated disorders associated with free radicals.


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