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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

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Antiproliferative Effects of a Triterpene-Enriched Extract from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), on Human Lung Cancer Cells

Volume 20, Edição 12, 2018, pp. 1173-1183
DOI: 10.1615/IntJMedMushrooms.2018028823
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RESUMO

Ganoderma lucidum, a mushroom that has been used to treat disease in East Asia for centuries, has been shown to be effective against many types of tumors, but the exact cellular mechanism of action is unknown. In this study we examined proliferation of a lung cancer cell line after treatment with 12 concentrations of powdered G. lucidum for 24, 48, and 120 hours. Based on half-maximal inhibitory concentrations values, proliferation of the H1793 cell line seemed to be sensitive to the extract in a time- and dose-dependent manner. We used immunoblot analysis to examine the amounts of cell cycle proteins (cyclin D, Cdk4, and Cdc2) and apoptotic proteins (Bcl-xL and Bax) after treatment with a range of G. lucidum concentrations. Changes in amounts of proteins that regulate the cell cycle were consistent with longer G1 and G2 phases. Proapoptotic protein (Bax) levels increased 6.5-fold, with a commensurate increase in the Bax-to-Bcl ratio, especially at 48 and 120 hours. These results suggest that the decrease in cellular proliferation correlated with a change in both cell cycle progression and apoptosis, and that the triterpenoid in G. lucidum is the bioactive component. Further biochemical characterization of this ancient herbal remedy could hold promise for treating lung cancer.

CITADO POR
  1. Liu Wei, Yang Binbin, Yang Lu, Kaur Jasmine, Jessop Calvin, Fadhil Rushdi, Good David, Ni Guoying, Liu Xiaosong, Mosaiab Tamim, Yi Zhengjun, Wei Ming Q., Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers, Evidence-Based Complementary and Alternative Medicine, 2019, 2019. Crossref

  2. Molina D.S., Gutierrez J.B., Machado O.D., Mas D., Martinez Y., Nutraceutical Effect of Ganoderma lucidum Fungus on Neonatal Broilers Diet, International Journal of Poultry Science, 18, 12, 2019. Crossref

  3. Wang Zhuo, Wang Hongling, Kang Zongli, Wu You, Xing Yao, Yang Yuhong, Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium, Archives of Microbiology, 202, 7, 2020. Crossref

  4. Ahmad Md Faruque, Ganoderma lucidum: A rational pharmacological approach to surmount cancer, Journal of Ethnopharmacology, 260, 2020. Crossref

  5. Liu Jun, Yang Feng, Cheng Maofeng, Zhang Yan, Spinal cord injury can be relieved by the polysaccharides of Tricholoma matsutake by promoting axon regeneration and reducing neuroinflammation, NeuroReport, 31, 14, 2020. Crossref

  6. Zhu Liping, Wu Min, Li Peng, Zhou Yanfei, Zhong Jinyi, Zhang Zhiqiang, Li Ye, Yao Weixi, Xu Jianhua, High-Pressure Supercritical CO2 Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway, Frontiers in Pharmacology, 11, 2020. Crossref

  7. Yadav Rati, Das Joydeep, Lalhlenmawia H., Tonk Rajiv K., Singh Lubhan, Kumar Deepak, Targeting cancer using phytoconstituents-based drug delivery, in Advanced Drug Delivery Systems in the Management of Cancer, 2021. Crossref

  8. Martínez Y, Paredes J, Avellaneda MC, Botello A, Valdivié M, Diets with Ganoderma lucidum Mushroom Powder and Zinc-Bacitracin on Growth Performance, Carcass Traits, Lymphoid Organ Weights and Intestinal Characteristics in Broilers, Brazilian Journal of Poultry Science, 24, 1, 2022. Crossref

  9. Cao Liping, Jin Hongliu, Liang Qi, Yang Haiyi, Li Shuguang, Liu Zhicheng, Yuan Zhongwen, A new anti-tumor cytotoxic triterpene from Ganoderma lucidum, Natural Product Research, 36, 16, 2022. Crossref

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