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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v7.i12.130
pages 127-140

The Chemistry, Nutritional Value, Immunopharmacology, and Safety of the Traditional Food of Medicinal Split-Gill Fugus Schizophyllum commune Fr.:Fr. (Schizophyllaceae). A Literature Review

Christopher Hobbs
Institute for Natural Products Research, Davis, CA 95065; and Institute for Natural Products Research, 4731 East Fork Rd., Williams, OR 97544, USA

RESUMO

The cosmopolitan wood-loving mushroom, Schizophyllum commune, is used as a traditional food throughout Southeast Asia and India. Researchers have intensively studied a (13)-β-D-glucan from the mycelium extract, schizophyllan (SPG) since the 1970s, and today it is used as a biological response modifier (BRM) in combination with chemo- and radiation therapy, especially for cervical and gastric cancers. Based on an abundance of preliminary evidence showing binding of its (13)-β-D-glucan to dectin-1 receptors of macrophages and other cells, activation of a T-cell cascade with subsequent increased production of cytokines, such as interleukins and tumor necrosis factor (TNF-α), reduction of tumor size and growth, increased survival of tumor-bearing animals, and a few controlled human trials of varying methodologies and quality, it continues to be used in clinical practice. Larger, well-designed clinical trials are needed to secure its place in modern medical practice in other countries. Fundamental questions such as whether oral application is effective, determination of proper dose, frequency and length of administration, and whether SPG is effective with other types of cancer still need to be answered.


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