Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i1.20
14 pages

Antitumor Activity and Hematopoietic Response of a b-Glucan Extracted from an Edible and Medicinal Mushroom Sparassis crispa Wulf.: Fr. (Aphyllophoromycetideae)

Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Toshie Harada
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Shinya Masuzawa
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Mitsuhiro Nakajima
Minahealth Co. Ltd., Saitama, Japan
Toshiro Yadomae
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

RESUMO

Sparassis crispa Wulf.: Fr. is an edible and medicinal mushroom recently cultivated in Japan. It contains a high content (~ 40%) of 6-branched 1,3-b-D-glucan showing antitumor activity. Oral administration of the (b-glucan fraction CA1, extracted with cold sodium hydroxide, enhanced the hematopoietic response in cyclophosphamide (CY)-induced leukopenic mice assessed by white blood cell count. Analyzing the leukocyte population by flow cytometry, the rate of leukocyte recovery in CY-administered mice was different in each population, such as granulocyte, monocyte, natural killer cell, В cell, Т cell, and so on. Administration of CA1 modulated the recovery rate of each population. In Peyer's patches, recovery of the T/B ratio was faster than in the control group. In in vitro, CY-treated spleen cell culture, interleukin-6 and interferon-g production was enhanced by CA1 treatment. These facts strongly suggested that the enhanced hematopoietic response by CA1 is due to enhanced cytokine production.


Articles with similar content:

Comparison of the Immunomodulating Activities of 1,3-β-glucan Fractions from the Culinary-Medicinal Mushroom Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 3
Yoshiyuki Adachi, Noriko N. Miura, Hiromi Kawaminami, Toshiro Yadomae, Mitsuhiro Nakajima, Naohito Ohno, Toshie Harada
Oral Administration of Soluble β-Glucan Preparation from the Cauliflower Mushroom, Sparassis crispa (Higher Basidiomycetes) Modulated Cytokine Production in Mice
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 6
Yoshiyuki Adachi, Noriko N. Miura, Hiromi Kawaminami, Naohito Ohno, Ken-Ichi Ishibashi, Toshie H. Hida
Effects of 10-GHz Microwaves on Hematological Parameters in Swiss Albino Mice and Their Modulation by Prunus avium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
K. V. Sharma, Rashmi Sisodia, Preeti Srivastava, Faiza Rifat, Archana Sharma
Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 4
Rosalia Rubel, Leandro Freire dos Santos, Carlos Ricardo Soccol, Luiz Claudio Fernandes, Herta Stutz Dalla Santa, Bonald Cavalcante Figueiredo
Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 5
Mohitosh Mandal, Birendra Behera, Sujit Kumar Bhutia, Swatilekha Maiti, Tapas K Maiti, Sanjaya Kumar Mallick