Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
In Vivo Iron-Chelating Activity and Phenolic Profiles of the Angel's Wings Mushroom, Pleurotus porrigens (Higher Basidiomycetes)
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RESUMO
Pleurotus porrigens is an culinary-medicinal mushroom. It is locally called sadafi and is found in the northern regions of Iran, especially in Mazandaran. This mushroom is used to prepare a variety of local and specialty foods. Because of the phenol and flavonoid contents and the strong iron-chelating activity of this mushroom, it was selected for an assay of in vivo iron-chelating activity. Methanolic extract was administered intraperitoneally to iron-overloaded mice at two dosages (200 and 400 mg/kg/24 hours) for a total of 20 days, with a frequency of 5 times a week for 4 successive weeks. The total iron content was determined by atomic absorption spectroscopy. Plasma Fe3+ content was determined using a kit. Liver sections were stained by hematoxylin and eosin and Perls stain. A significant decrease in the plasma concentration of iron was observed in mice treated with extracts (P < 0.001). The animals showed a dramatic decrease in plasma Fe3+ content when compared with the control group (P < 0.001). Also, Perls stain improved the smaller amount of deposited iron in the liver of iron-overloaded mice treated with the extract. Liver sections revealed a marked reduction in the extent of necrotic hepatocytes, fibrous tissues, and pseudo-lobules. A high-performance liquid chromatography method was developed to simultaneously separate 7 phenolic acids in extract. Rutin (1.784 ± 0.052 mg g−1 of extract) and p-coumaric acid (1.026 ± 0.043 mg g−1 of extract) were detected as the main flavonoid and phenolic acids in extract, respectively. The extract exhibited satisfactory potency to chelate excessive iron in mice, potentially offering new natural alternatives to treat patients with iron overload. More studies are needed to determine which compounds are responsible for these biological activities.
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Aalikhani Mahdi, Safdari Yagoub, Jahanshahi Mehrdad, Alikhani Mehrdad, Khalili Masoumeh, Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice, Frontiers in Neuroscience, 15, 2022. Crossref
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Vieira Gomes Débora Cássia, de Alencar Marcus Vinícius Oliveira Barros, dos Reis Antonielly Campinho, de Lima Rosália Maria Torres, de Oliveira Santos José Victor, da Mata Ana Maria Oliveira Ferreira, Soares Dias Ana Carolina, da Costa Joaquim Soares, de Medeiros Maria das Graças Freire, Paz Márcia Fernanda Correia Jardim, Gayoso e Almendra Ibiapina Moreno Lina Clara, Castro e Sousa João Marcelo de, Islam Muhammad Torequl, Melo Cavalcante Ana Amélia de Carvalho, Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action, Biomedicine & Pharmacotherapy, 112, 2019. Crossref
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Alikhani Mehrdad, Aalikhani Mahdi, Khalili Masoumeh, Reduction of iron toxicity in the heart of iron-overloaded mice with natural compounds, European Journal of Pharmacology, 924, 2022. Crossref
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Jahanshahi Mehrdad, Khalili Masoumeh, Margdari Asra, Aalikhani Mahdi, Naringin is a promising natural compound for therapy of iron-overload disorders, Brazilian Journal of Pharmaceutical Sciences, 58, 2022. Crossref
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AAlikhani Mahdi, Khalili Masoumeh, Jahanshahi Mehrdad, The natural iron chelators' ferulic acid and caffeic acid rescue mice's brains from side effects of iron overload, Frontiers in Neurology, 13, 2022. Crossref