Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i8.60
pages 699-711

Metabolomic Investigation of Rat Serum Following Oral Administration of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), by UPLC-HDMS

Yu Dong
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China; Zhejiang Chinese Medical University, Hangzhou, China
Ying He
Zhejiang Chinese Medical University, Hangzhou, China
Zhongming Yu
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Yang Zhang
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Nani Wang
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Dan Shou
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China; Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China
Changyu Li
Zhejiang Chinese Medical University, Hangzhou, China

RESUMO

The medicinal willow bracket mushroom, Phellinus igniarius, is a species that has been reported to possess antibacterial, antioxidative, antitumor, antidiabetic, and antihyperlipidemia activities. The aim of this study was to elucidate the changes in endogenous metabolites after oral administration of a decoction of Ph. Igniarius. Ultraperformance liquid chromatography (UPLC)/electrospray ionization synapt high-definition mass spectrometry (ESI-HDMS) combined with pattern recognition approaches, including principal component analysis and orthogonal partial least squares discriminant analysis, were integrated to discover differentiating metabolites. The current metabolomics approach identified 16 ions (5 in the negative mode, 11 in the positive mode) as "differentiating metabolites". The results illustrated that Ph. Igniarius is likely to increase the biosynthesis and secretion of bile acids that provide hypolipidemic activity and showed that robust UPLC/ESI-HDMS techniques are promising for profiling analysis of medicinal mushroom metabolites.


Articles with similar content:

Preparative Isolation of 5 Antioxidant Constituents from the Medicinal Mushroom Phellinus baumii (Agaricomycetes) by High-Speed Countercurrent Chromatography and Preparative High-Performance Liquid Chromatography
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 4
Yan Yang, Hongjian Zheng, Libin Ye, Zhong Zhang
Submerged Cultivation of Medicinal Mushrooms: Bioprocesses and Products (Review)
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 3
Vladimir I. Elisashvili
Estrogenic Substances from the Mycelia of Medicinal Fungus Cordyceps ophioglossoides (Ehrh.) Fr. (Ascomycetes)
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 3
Noriko Kinjo, Hirokazu Kawagishi, Fumio Kobayashi, Kentaro Okamura
Occurrence and Identification of Chalcones from the Culinary-Medicinal Cauliflower Mushroom Sparassis crispa (Wulf.) Fr. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 4
Munehiko Dombo, Hirokazu Kawagishi, Takashi Kimura, Mamiko Hashimoto, Kanako Hayashi, Sinji Tokuyama
β-(1→3)-Glucan of the Southern Bracket Mushroom, Ganoderma australe (Agaricomycetes), Stimulates Phagocytosis and Interleukin-6 Production in Mouse Peritoneal Macrophages
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 4
Renan Henrique de Melo, Rafael Andrade Menolli, Jose Luis da Conceicao Silva, Arquimedes Paixao de Santana-Filho, Marina Kimiko Kadowaki, Guilherme Lanzi Sassaki, Rita de Cassia Garcia Simao, Thais Soprani Ayala, Alex Evangelista do Amaral