Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/InterJMedicMush.v5.i4.30
10 pages

Immunomodulating Activity of a b-Glucan Preparation, SCG, Extracted from a Culinary–Medicinal Mushroom, Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae), and Application to Cancer Patients

Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Sachiko Nameda
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
Toshie Harada
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Mitsuhiro Nakajima
Minahealth Co. Ltd., Saitama, Japan
Kenshi Yoshida
Omotesando Yoshida Hospital, Kumamoto-city, Kumamoto, Japan
Hitoji Yoshida
Omotesando Yoshida Hospital, Kumamoto-city, Kumamoto, Japan
Toshiro Yadomae
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

RESUMO

Sparassis crispa (SC) is culinary–medicinal mushroom recently cultivated in Japan, China, Germany, and the US. We purified a 6-branched 1.3-b-D-glucan preparation designated as SCG. SCG increased the number of leukocytes and enhanced the activity of leukocytes from various points of view, mainly analyzed in experimental animals. In the present study, the cytokine capacity of SCG was examined in healthy volunteers in vitro, and the following characteristics were studied: SCG enhanced cytokine synthesis of whole blood cell culture dose dependently. A complement fragment, C5a, was released by SCG dependently upon dose. And anti-SCG natural antibody was detected in human plasma. From these facts, SCG has the capacity to activate human leukocytes and related immune systems. In a clinical trial, powder of SC (300 mg/day) was given orally to several cancer patients (lung, stomach, colon, breast, ovarian, uterine, prostate, pancreas, liver) after one course of treatment of lymphocyte transfer immunotherapy and follow-up for several months. Performance status of 14 cases were monitored and 9 cases were improved as CR (4), PR (5), and NC (5). These facts strongly suggest that Sparassis crispa is a good source for cancer immunotherapy.


Articles with similar content:

Dendritic Cell-Based Immunotherapy of Prostate Cancer
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
H. Ragde, M. L. Salgaller, P. A. Lodge, B. A. Tjoa, G. P. Murphy, G. Kenny, A. Boynton
T-Cell Receptor-Derived Peptides in Immunoregulation and Therapy of Retrovirally Induced Immunosuppression
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Ian F. Robey, Ronald R. Watson, R. Tomas Sepulveda, Allen B. Edmundson, John J. Marchalonis
Antitumor Polysaccharides from Edible and Medicinal Mushrooms and Immunomodulating Action Against Murine Macrophages
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 4
Hitoshi Ashida, Takashi Hashimoto, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno
Reactive Oxygen Species, Antioxidant Mechanisms, and Serum Cytokine Levels in Cancer Patients: Impact of an Antioxidant Treatment
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 1
Clelia Madeddu, Loredana Mura, Elena Massa, Viviana Murgia, Giulia Gramignano, Giovanni Mantovani, Maria Rita Lusso, Paolo Camboni, Luca Ferreli, Antonio Maccio
Combination Therapy of Transplanted Meth-A Fibrosarcoma in BALB/c Mice with Protein-Bound Polysaccharide EA6 Isolated from Enokitake Mushroom Flammulina velutipes (W.Curt.:Fr.)Singer and Surgical Excision
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Tetsuro Ikekawa, Hirofumi Maruyama