Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
In Vitro Antioxidant and In Vivo Hypolipidemic Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in Rats with High-Fat Diet–Induced Fatty Liver and Hyperlipidemia
RESUMO
We investigated the effect of the culinary-medicinal mushroom Pleurotus eryngii var. ferulae DDL01 on oxidative damage in the liver and brain and a high-fat/high-cholesterol–induced hyperlipidemic model. In in vitro studies, the water extracts of the fruiting bodies showed strong scavenging activities of DPPH (139.46 ± 3.2 μg) and hydroxyl (139.46 ± 3.2 μg) radicals. Moreover, the extracts showed Fe2+ chelating and reducing abilities, as well as a large amount of polyphenols and an inhibitory effect on lipid peroxidation in the liver and brain tissues. The rats were fed a pellet diet (7.5 g/rat/day) containing P. eryngii var. ferulae DDL01 (PD) for 3 weeks. In the high-fat/high-cholesterol–induced hyperlipidemic rat model, administration of PD caused a significant decrease (P < 0.05) in the levels of serum triacylglycerols, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, aspartate aminotransferase, and alanine aminotransferase and a significant increase (P < 0.05) in the level of high-density lipoprotein cholesterol. PD administration significantly decreased high-fat/high-cholesterol–induced hepatic lipid accumulation. Treatment with the extracts (up to 500 μg/mL) did not significantly affect the viability of HepG2 and 3T3-L1 cells. Our findings suggest that this mushroom has potential as an antiatherogenic dietary source in the development of therapeutic agents and functional foods.
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Li Qiang, Chen Cheng, Xiong Chuan, Jin Xin, Chen Zuqin, Huang Wenli, Comparative mitogenomics reveals large-scale gene rearrangements in the mitochondrial genome of two Pleurotus species, Applied Microbiology and Biotechnology, 102, 14, 2018. Crossref
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Yang Xiaoqian, Lin Ping, Wang Jin, Liu Na, Yin Fan, Shen Nuo, Guo Shoudong, Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris, International Journal of Biological Macromolecules, 181, 2021. Crossref
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Mustafa Faheem, Chopra Hitesh, Baig Atif Amin, Avula Satya Kumar, Kumari Sony, Mohanta Tapan Kumar, Saravanan Muthupandian, Mishra Awdhesh Kumar, Sharma Nanaocha, Mohanta Yugal Kishore, Edible Mushrooms as Novel Myco-Therapeutics: Effects on Lipid Level, Obesity and BMI, Journal of Fungi, 8, 2, 2022. Crossref
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dos Reis Eduardo Echer, Schenkel Paulo Cavalheiro, Camassola Marli, Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular system, Journal of Integrative Medicine, 20, 5, 2022. Crossref