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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice

Volume 13, Edição 3, 2011, pp. 227-236
DOI: 10.1615/IntJMedMushr.v13.i3.20
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RESUMO

Turkey tail medicinal mushroom, Trametes versicolor (TV), is a species with a variety of pharmacological activities. Its intracellular polysaccharopeptides are widely commercialized. Recently, we found a novel TV strain LH-1 in Taiwan and demonstrated that the extracellular polysaccharopeptide (ePSP) of LH-1 obtained from submerged culture exhibits significant immunomodulatory activity. In this in vivo study, we further evaluated the safety of orally administered LH-1 ePSP using both male and female ICR mice. The LH-1 ePSP was orally administered to mice at levels of 0 (water), 100 (low dose), 500 (medium dose), or 1000 mg/kg/day (high dose) for 28 days. Clinical observations, growth, food consumption, histopathological examination, and clinical biochemical analyses revealed no adverse effects of LH-1 ePSP in mice. There were no significant differences in the results of target organ weights, hematological analyses, and urinalysis examination among groups. However, male mice that ingested high doses of LH-1 ePSP tended to have decreased lung weights and platelet numbers. In conclusion, the results of the present study suggested that oral administration of LH-1 ePSP for 28 days is accompanied by no obvious signs of toxicity. The lack of toxicity supports the potential use of LH-1 ePSP as a food or dietary supplement.

CITADO POR
  1. VanderMolen Karen M., Little Jason G., Sica Vincent P., El-Elimat Tamam, Raja Huzefa A., Oberlies Nicholas H., Baker Timothy R., Mahony Catherine, Safety assessment of mushrooms in dietary supplements by combining analytical data with in silico toxicology evaluation, Food and Chemical Toxicology, 103, 2017. Crossref

  2. Teng Ju-Fang, Lee Chien-Hsing, Hsu Tai-Hao, Lo Hui-Chen, Essop M. Faadiel, Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells, PLOS ONE, 13, 7, 2018. Crossref

  3. Le Bao, Anh Pham-Thi-Ngoc, Yang Seung-Hwan, Polysaccharide Derived from Nelumbo nucifera Lotus Plumule Shows Potential Prebiotic Activity and Ameliorates Insulin Resistance in HepG2 Cells, Polymers, 13, 11, 2021. Crossref

  4. Cerig Salim, A safety assessment of hot aqueous mycelium extracts from Trametes versicolor and Lepista nuda as a food supplement, Biologia, 76, 8, 2021. Crossref

  5. Chen Chung-Hwan, Kang Lin, Lo Hui-Chen, Hsu Tai-Hao, Lin Fang-Yi, Lin Yi-Shan, Wang Zai-Jie, Chen Shih-Tse, Shen Chwan-Li, Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats, Journal of Agricultural and Food Chemistry, 63, 42, 2015. Crossref

  6. Hsu Wen-kuang, Hsu Tai-hao, Lin Fang-yi, Cheng Yuan-kai, Yang John Po-wen, Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia, Carbohydrate Polymers, 92, 1, 2013. Crossref

  7. Feng Zifang, Wang Zhixue, Yang Min, Zhou Lijing, Bao Yixi, Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway, International Journal of Biological Macromolecules, 82, 2016. Crossref

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