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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i2.90
pages 187-190

Thrombolytic Activity of Mushroom Proteinases: Thrombolytic Activity of Proteinases from Coprinus domesticus, C. cinereus, and Cerrena unicolor

Nina P. Denisova
V. L. Komarov Botanical Institute Russian Academy of Sciences Prof. Popova Str. 2 St. Petersburg 197376, Russia
Vladimir N. Mikhailov
Department of Pathological Physiology, Acad. I. P. Pavlov Saint Petersburg State Medical University, L.Tolstoy Str., 6/8, Saint Petersburg 197022(1), Russia
Nickolay N. Petrishchev
Department of Pathological Physiology, Acad. I. P. Pavlov Saint Petersburg State Medical University, L.Tolstoy Str., 6/8, Saint Petersburg 197022(1), Russia

RESUMO

Fibrinolytic and thrombolytic activity of extracellular enzyme complexes from the cultures of coprotrophic mushrooms Coprinus domesticus (Bolt.: Fr.) S. F. Gray and С. Cinnereus (Schaeff.: Fr.) S. F. Gray, as well as xylotrophic mushroom, Cerrena unicolor (Bull.: Fr.) Murr., were investigated during biomedical experiments in vitro and in vivo. It was shown that enzyme complexes isolated from C. domesticus, C. cinereus, and Cerrena unicolor possess a large affinity for fibrin and cause fibrin lysis. In addition, a direct and stable thrombolytic effect developed, proving more significant in fresh thrombosis.


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