Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019031175
pages 683-691

Wound Healing Activity of a Skin Substitute from Residues of Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes) Cultivation

Hui Xu
shenyang pharmaceutical university; Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Liangyun Liu
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Chongjiang Cao
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Weisheng Lu
State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, P.R. China
Zhenhan Zhu
Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, P.R. China
Zijun Guo
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Min Li
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Xing Wang
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Dechun Huang
Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, P.R. China
Suilou Wang
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Shujie Cheng
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China

RESUMO

A skin substitute TG05 obtained from residues of the culinary-medicinal mushroom Flammulina velutipes cultivation process was developed in this study for the first time. Pre-column derivatization high-performance liquid chromatography fingerprints analysis revealed that TG05 was composed of water-insoluble fibers containing xylose (57%), glucose (19.5%), and arabinose (16.3%) as major monomers. Porous and opaque structure of TG05 was demonstrated by scanning electron microscopy. Animal experiments conducted on mice and rats indicated that TG05 notably accelerated the wound-healing process. In addition, TG05 induced proliferation and migration of human keratinocytes time- and dose-dependently. Taken together, the skin substitute TG05 with new structure promotes wound healing in vitro and in vivo. This study provided a novel method to produce functional biomaterial from abundant and low-cost agricultural residues generated during edible mushroom cultivation.

Referências

  1. Wang Q, Zhang J, Li C, Wang B, Nong W, Bian Y, Xiao Y. Phenotypic and genetic diversity of the culinary-medicinal winter mushroom Flammulina velutipes (Agaricomycetes) in China. Int J Med Mushrooms. 2018;20(6):517-36.

  2. Su A, Yang W, Zhao L, Pei F, Yuan B, Zhong L, Ma G, Hu Q. Flammulina velutipes polysaccharides improve scopolamine-induced learning and memory impairment in mice by modulating gut microbiota composition. Food Funct. 2018;9(3):1424-32.

  3. Jia W, Feng J, Zhang JS, Lin CC, Wang WH, Chen HG. Structural characteristics of the novel polysaccharide FVPA1 from winter culinary-medicinal mushroom, Flammulina velutipes (Agaricomycetes), capable of enhancing natural killer cell activity against K562 tumor cells. Int J Med Mushrooms. 2017;19(6):535-46.

  4. Feng T, Jia W, Wang WH, Lin CC, Fan H, Zhang JS, Bao HY Structural characterization and immunological activities of a novel water-soluble polysaccharide from the fruiting bodies of culinary-medicinal winter mushroom, Flammulina velutipes (Agaricomycetes). Int J Med Mushrooms. 2016;18(9):807-19.

  5. Dong YR, Cheng SJ, Qi GH, Yang ZP, Yin SY, Chen GT. Antimicrobial and antioxidant activities of Flammulina velutipes polysaccharides and polysaccharide-iron(HI) complex [corrected]. Carbohydr Polym. 2017;161:26-32.

  6. Kishikawa A, Ashour A, Zhu Q, Yasuda M, Ishikawa H, Shimizu K. Multiple biological effects of olive oil by-products such as leaves, stems, flowers, olive milled waste, fruit pulp, and seeds of the olive plant on skin. Phytother Res. 2015;29(6):877-86.

  7. de Menezes TA, Bispo AS, Koblitz MG, Vandenberghe LP, Kamida HM, Goes-Neto A. Production of basidiomata and ligninolytic enzymes by the lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), in Licuri (Syagrus coronata) wastes in Brazil. Int J Med Mushrooms. 2016;18(L2):1141-49.

  8. Song X, Liu M, Wu D, Qi L, Ye C, Jiao J, Hu F. Heavy metal and nutrient changes during vermicomposting animal manure spiked with mushroom residues. Waste Manag. 2014;34(11):1977-83.

  9. Luo D, Xie YF, Tan ZL, Li XD. Removal of Cu<sup>2&#43;</sup> ions from aqueous solution by the abandoned mushroom compost of Flammulina velutipes. J Environ Biol. 2013;34(2 Spec No):359-65.

  10. Liu Y, Zhang B, Ibrahim SA, Gao SS, Yang H, Huang W. Purification, characterization and antioxidant activity of polysaccharides from Flammulina velutipes residue. Carbohydr Polym. 2016;145:71-7.

  11. Mahfuz S, Song H, Liu Z, Liu X, Diao Z, Ren G, Guo Z, Cui Y Effect of golden needle mushroom (Flammulina velutipes) stem waste on laying performance, calcium utilization, immune response and serum immunity at early phase of production. Asian-Austral J Anim Sci. 2018;31(5):705-11.

  12. Chen GT, Fu YX, Yang WJ, Hu QH, Zhao LY Effects of polysaccharides from the base of Flammulina velutipes stipe on growth of murine RAW264.7, B16F10 and L929 cells. Int J Biol Macromol. 2018;107(Pt B):2150-6.

  13. Liu W, Xu J, Zhu R, Zhu Y, Zhao Y, Chen P, Pan C, Yao W, Gao X. Fingerprinting profile of polysaccharides from Lycium barbarum using multiplex approaches and chemometrics. Int J Biol Macromol. 2015;78:230-7.

  14. Lv Y, Yang X, Zhao Y, Ruan Y, Yang Y, Wang Z. Separation and quantification of component monosaccharides of the tea polysaccharides from Gynostemma pentaphyllum by HPLC with indirect UV detection. Food Chem. 2009;112(3):742-6.

  15. Su CH, Sun CS, Juan SW, Hu CH, Ke WT, Sheu MT. Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes. Biomaterials. 1997;18(17):1169-74.

  16. Jiang PL, Chien MY, Sheu MT, Huang YY, Chen MH, Su CH, Liu DZ. Dried fruit of the Luffa sponge as a source of chitin for applications as skin substitutes. Biomed Res Int. 2014;2014:1-9.

  17. Su CH, Liu SH, Yu SY, Hsieh YL, Ho HO, Hu CH, Sheu MT. Development of fungal mycelia as a skin substitute: characterization of keratinocyte proliferation and matrix metalloproteinase expression during improvement in the wound-healing process. J Biomed Mater Res A. 2005;72(2):220-7.

  18. Frederick J, Boysen S, Wagg C, Chalhoub S. The effects of oral administration of Yunnan Baiyao on blood coagulation in beagle dogs as measured by kaolin-activated thromboelastography and buccal mucosal bleeding times. Can J Vet Res. 2017;81(1):41-5.

  19. Li R, Alex P, Ye M, Zhang T, Liu L, Li X. An old herbal medicine with a potentially new therapeutic application in inflammatory bowel disease. Int J Clin Exp Med. 2011;4(4):309-19.

  20. Murphy LA, Panek CM, Bianco D, Nakamura RK. Use of Yunnan Baiyao and epsilon aminocaproic acid in dogs with right atrial masses and pericardial effusion. J Vet Emerg Crit Care (San Antonio). 2017;27(1):121-6.

  21. Wirth KA, Kow K, Salute ME, Bacon NJ, Milner RJ. In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines. Vet Comp Oncol. 2016;14(3):281-94.

  22. Evora A, de Freitas V, Mateus N, Fernandes I. The effect of anthocyanins from red wine and blackberry on the integrity of a keratinocyte model using ECIS. Food Funct. 2017;8(11):3989-98.

  23. Patruno A, Ferrone A, Costantini E, Franceschelli S, Pesce M, Speranza L, Amerio P, D'Angelo C, Felaco M, Grilli A, Reale M. Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines. Cell Prolif. 2018;51(2):e12432.

  24. Song G, Banov D, Bassani AS. Effects of compounded Stanford modified oral rinse (MucoLox) on the survival and migration of oral keratinocytes and fibroblasts: implications for wound healing. Int J Pharm Compd. 2018;22(1):60-5.


Articles with similar content:

Determination of the Biological Efficiency and Antioxidant Potential of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Cultivated Using Different Agro-Wastes in Malaysia
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 1
Ibrahim Alzorqi, Yasmeen Siddiqui, Sivakumar Manickam, Surya Sudheer, Asgar Ali, Poh Guat Cheng
Mechanism of Glucose Regulates the Fruiting Body Formation in the Beech Culinary-Medicinal Mushroom, Hypsizygus marmoreus (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 2
Min-Ying Xie, Ming-Jie Chen, Hong Wang, Jin-Jing Zhang, Zhi-Yong Feng, Hai-Bo Hao, Hui Chen
Flammulin Purified from the Fruit Bodies of Flammulina velutipes (Curt.:Fr.) P.Karst.
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Feng Gong, Hua Zhang, Yongjun Feng, Changkai Zhang
Study of Hypsizygus marmoreus (Peck) Bigel. and Grifola frondosa (Dicks.: Fr.) S.F. Gray: Cultural-Morphological Peculiarities, Growth Characteristics, Qualitative Enzymatic Activity, and Resistance to Fungal Pest Contamination
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 4
Alexander Beharav, Eden Akavia, Eviatar D. Nevo
Structural Characterization and Immunological Activities of a Novel Water-Soluble Polysaccharide from the Fruiting Bodies of Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 9
Ting Feng, Jing-Song Zhang, Chi-Chung Lin, Wei Jia, Wenhan Wang, Hua Fan, Hai-Ying Bao