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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i1.10
pages 1-10

Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats

Chun-Jing Zhang
Department of Biochemistry, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China
Xiulan Gao
Shandong College of Chinese Medicine, Shandong Yantai, PR China
Yan Sun
Department of Clinical Pathogenic Microorganisms, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Xiaojie Sun
Qiqihar Medical University, Heilongjiang Qiqihar, China
Yanmin Wu
Qiqihar Medical University, Heilongjiang Qiqihar, China
Ying Liu
Heilongjiang Nursing College, Heilongjiang Harbin, China
Haitao Yu
Department of Biochemistry and Molecular Biology, Harbin Medical University, Heilongjiang Harbin; Department of Biology Genetics, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Guangcheng Cui
Departments of Clinical Psychology, Qiqihar Medical University, Heilongjiang Qiqihar, China

RESUMO

We investigated the anxiolytic effects Agaricus brasiliensis extract (AbSE) on ischemia-induced anxiety using the plus-maze test and the social interaction test. The animals were treated orally with AbSE (4, 8, and 10 mg/kg/d, respectively) for 30 d, followed by middle cerebral artery occlusion-induced cerebral ischemia. Levels of noradrenaline, dopamine, and serotonin in the cerebral cortex of rats, as well as oxidative stress and plasma corticosterone levels were analyzed, respectively. The rota-rod test was carried out to exclude any false positive results in experimental procedures related to anxiety disorders, and the catalepsy test was carried out to investigate whether AbSE induces catalepsy. Our results demonstrate that oral administration of AbSE presented anxiolytic-like effects in the elevated plus-maze test and the social interaction test. Furthermore, AbSE did not induce extrapyramidal symptoms in the catalepsy test. The mechanism underlying the anxiolytic effect of AbSE might be increased brain monoamine levels and plasma corticosterone levels and decreased oxidative stress in cerebral ischemia/reperfusion rats.


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