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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i1.30
pages 21-28

Antiarthritic Activity of a Polysaccharide-Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae) in Freund's Complete Adjuvant−Induced Arthritic Rats

Chakrapully R. Meera
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Thozhuthumparambil P. Smina
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680 555, India
Balan Nitha
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
John Mathew
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India

RESUMO

Arthritis is a common disease affecting millions, and the treatments available are generally palliative. Nonsteroidal anti-inflammatory drugs (NASIDs) are widely used clinically to treat inflammatory diseases and rheumatoid arthritis. Free radicals have long been implicated in the change in connective tissues in inflammation and arthritis. Lipid-peroxide formation as well as altered levels of endogenous free-radical scavengers, such as superoxide dismutase, glutathione peroxidase, and reduced glutathione, have been considered as indirect in vivo evidence for the participation of free radicals in the progression of arthritis. A polysaccharide-protein complex (PPC-Pr) isolated from Phellinus rimosus (Berk.) Pilát growing on jack fruit trees in India was investigated to find out its inhibitory effect on Freund's complete adjuvant (FCA)-induced arthritis in rats. A significant increase in lipid-peroxide levels in the plasma of adjuvant-induced arthritic rats was observed. The antioxidant enzymes superoxide dismutase and glutathione peroxidase were elevated in adjuvant-induced rats, and reduced blood glutathione was decreased. Treatments with various concentrations of PPC-Pr modulated the above alterations produced in arthritic animals in a dose-dependent manner. The results thus suggested the therapeutic potential of PPC-Pr as a possible alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammatory diseases and rheumatoid arthritis.


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