Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy
Get access
RESUMO
Fomitopsis pinicola (Sw.) P. Karst. (Fomitopsidaceae) is a medicinal mushroom with a variety of healthy properties. In this study we tested the radical scavenging activity and antimicrobial and anticancer potential of methanol extracts of F. pinicola from central Italy. Molecular identification confirmed that the samples were F. pinicola; a Basic Local Alignment Search Tool search showed a close match (99% sequence identity) with European isolates of this species. The free radical scavenging capacities, measured by DPPH assay, showed that the extract activity was 3.5% that of Trolox. The MTT test, evaluated after 72 hours of treatment with increasing doses of extract (5-500 μg · mL-1), considerably inhibited proliferation in a dose-dependent manner in 2 human tumor cell lines. This reduction was coupled with a relevant induction of apoptosis in the human leukemia THP-1 cell line after 24 hours of treatment, but a relevant toxic effect occurred in the human colon adenocarcinoma HT29 cell line. The genotoxic potential of the methanol extracts was studied by single-cell gel electrophoresis of normal human leukocytes exposed to 20 μg extract at 37°C for 30 minutes; no DNA damage was observed. The F. pinicola methanol extract was found to have varying degrees of antifungal effects against the pathogenic fungi tested (minimum inhibitory concentration from 23.63 to 66.81 μg · mL-1). The results show that the tested F. pinicola extract has strong antimicrobial and chemo-preventive activities, but is a poor antioxidant.
-
Venanzoni Roberto, Bini Enrico, Bricchi Emma, Angelini Paola, Contribution to the knowledge of fungal diversity of the Marmore Waterfalls (Umbria, central Italy), Italian Botanist, 7, 2019. Crossref
-
Angelini Paola, Girometta Carolina, Tirillini Bruno, Moretti Simone, Covino Stefano, Cipriani Melania, D’Ellena Eleonora, Angeles Giancarlo, Federici Ermanno, Savino Elena, Cruciani Gabriele, Venanzoni Roberto, A comparative study of the antimicrobial and antioxidant activities of Inonotus hispidus fruit and their mycelia extracts, International Journal of Food Properties, 22, 1, 2019. Crossref
-
Angelini Paola, Venanzoni Roberto, Angeles Flores Giancarlo, Tirillini Bruno, Orlando Giustino, Recinella Lucia, Chiavaroli Annalisa, Brunetti Luigi, Leone Sheila, Di Simone Simonetta Cristina, Ciferri Maria Chiara, Zengin Gokhan, Ak Gunes, Menghini Luigi, Ferrante Claudio, Evaluation of Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Extracts from Tricholosporum goniospermum, an Edible Wild Mushroom, Antibiotics, 9, 8, 2020. Crossref
-
Angelini Paola, Matei Florentina, Flores Giancarlo Angeles, Pellegrino Roberto Maria, Vuguziga Lydie, Venanzoni Roberto, Tirillini Bruno, Emiliani Carla, Orlando Giustino, Menghini Luigi, Ferrante Claudio, Metabolomic Profiling, Antioxidant and Antimicrobial Activity of Bidens pilosa, Processes, 9, 6, 2021. Crossref
-
Kurchenko V., Sushinskaya N., Maiorava K., Tarun E., Kiseleva I., Biologically Active Substances of Extracts from Various Wood-Decay Fungi and Their Antioxidant Activity, in Intelligent Biotechnologies of Natural and Synthetic Biologically Active Substances, 408, 2022. Crossref
-
Angelini Paola, Girometta Carolina Elena, Venanzoni Roberto, Bertuzzi Gianluigi, Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref