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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i1.10
pages 1-20

New Scientific Approaches to Cancer Treatment: Can Medicinal Mushrooms Defeat the Curse of the Century?

Roumyana D. Petrova
Institute of Evolution, University of Haifa, Mount Carmel, Haifa; Migal-Galilee Technology Center, South Industrial Zone, Kiryat Shmona, Israel;Bulgarian Mycological Society, 23 Acad. G. Bonchev St., Sofia 1113, Bulgaria

RESUMO

Modern science has spread so broadly and deeply within the nature of organisms that researchers have already established the molecular mechanisms of each vital process of human existence. Unfortunately, our age, heredity, lifestyle, race, and ethnicity are directly connected to the development and expression of many negative and even fatal processes, such as carcinogenesis. Many investigators have shown that the roots of carcinogenesis are hidden in the signaling pathways of cancer cells. Therefore, the pharmacological modulation of intracellular signal transduction pathways and the activation of transcription factors regulating gene expression represent a new and attractive therapeutic approach to cancer. It is already well established that medicinal mushrooms represent a potential source for biologically active compounds with immunomodulating, free radical scavenging, anti-inflammatory, antibacterial, antifungal, antiviral, hepatoprotective, antidiabetic, and anticancer activities. Moreover, low−molecular weight mushroom substances have been studied, and reported to interact with particular intracellular signaling pathways related to processes such as inflammation, cell differentiation and survival, apoptosis, angiogenesis, tumor progression and metastasis, etc. The present work compiles the available data on mushroom substances, in the form of extracts or chemically defined compounds, known to interfere with the above-mentioned essential processes related to the carcinogenesis and, thus, representing a new scientific approach to cancer treatment and prevention.


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