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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Extracts from Culinary-Medicinal Mushrooms Increase Intracellular α-Defensins 1-3 Concentration in HL60 Cells

Volume 12, Edição 1, 2010, pp. 33-41
DOI: 10.1615/IntJMedMushr.v12.i1.30
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RESUMO

Exotic mushrooms have long been used in Asia for the treatment and prevention of diseases, including infections, due to their capacity to modulate immunity. However, their effect on the production of antimicrobial peptides α-defensins 1-3, an important component of innate immunity, has not been previously investigated. We hypothesized that one of the mechanisms by which mushrooms protect from infection is by the induction of α-defensins 1-3. We measured α-defensins 1-3 by ELISA in cell lysates of promyelocytic HL60 cells incubated with 0−10 μg/mL extracts of Agaricus bisporus (white strain and portabella), Grifola frondosa, and Lentinus edodes (prepared by ethanol precipitation), with and without lipopolysaccharides (2.5 μg/mL LPS), for 48 h. In LPS-treated and untreated cultures, the extracts increased cellular a-defensins levels by 131%−350% (p < 0.05, ANOVA). Boiling mushrooms for 10 or 30 min did not abrogate α-defensins induction, suggesting that the bioactive active compounds are heat stable. The mechanism of α-defensins 1-3 upregulation has yet to be investigated. However, we speculate that it is unlikely related to higher HL60 cell proliferation because mushroom extracts reduced 3H-thymidine uptake by up to 66% (p < 0.005). It also was not due to endotoxin because the levels were low (<0.06 EU/mL) and LPS did not increase α-defensins. This is the first time that culinary-medicinal mushrooms are shown to modulate α-defensins 1-3 production. Our data suggest that the induction of α-defensins 1-3 may contribute to the protective effect of mushrooms from infection.

CITADO POR
  1. Chandra Lawrance C., Traoré Djibril, French Christine, Marlow Denver, D’Offay Jean, Clarke Stephen L., Smith Brenda J., Kuvibidila Solo, White button, portabella, and shiitake mushroom supplementation up-regulates interleukin-23 secretion in acute dextran sodium sulfate colitis C57BL/6 mice and murine macrophage J.744.1 cell line, Nutrition Research, 33, 5, 2013. Crossref

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