Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i6.80
pages 559-564

Inhibition of Quorum Sensing in the Opportunistic Pathogenic Bacterium Chromobacterium violaceum by an Extract from Fruiting Bodies of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Higher Basidiomycetes)

Hu Zhu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Wei Liu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Baozhen Tian
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Huijun Liu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Shoujiao Ning
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China

RESUMO

Extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, inhibited quorum sensing in Chromobacterium violaceum CV026. G. lucidum fruiting bodies were milled and extracted with ethyl acetate. The crude extract was dissolved in an appropriate concentration of methanol, sterilized by filtration through a 0.22-μm membrane filter, and added to Ch. Violaceum CV026 cultures, which were used as an indicator to monitor quorum sensing inhibition. Inhibitory activity was measured by quantifying violacein production using a microplate reader. Methanol-soluble compounds extracted from G. lucidum significantly inhibited quorum sensing-controlled behavior in Ch. Violaceum in a concentration-dependent manner. The results suggest that compounds in G. lucidum might be useful to control and handle detrimental infections caused by human, animal, and plant pathogens. Further studies are in progress in our lab to isolate the specific compounds from G. lucidum extract, evaluate them as quorum sensing inhibitors, and analyze their mechanism of action.


Articles with similar content:

Cultivation of Medicinal Caterpillar Fungus, Cordyceps militaris (Ascomycetes), and Production of Cordycepin Using the Spent Medium from Levan Fermentation
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Ing-Lung Shih, Yi-Lin Chen, Fang-Chen Wu, Shu-Ming Chang
Methoxyflavones from New Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 8
Satoru Kaifuchi, Yhiya M. Amen, Kuniyoshi Shimizu
A Comparison Study of the Anticancerous Activity and Mechanism of Ethanolic Extracts from Different Ganoderma lucidum (W.Curt.:Fr.) Lloyd Strains
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Yang Qing-Yao, Mi Ke, Feng Hui-Qing, Zhou Yue-Qing, Xiao-Tong Yang, Xu-Quan Li
Effects of Comb Tooth Cap Medicinal Mushroom, Hericium ramosum (Higher Basidiomycetes) Mycelia on DPPH Radical Scavenging Activity and Nerve Growth Factor Synthesis
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 4
Yoshihiro Sekino, Takafumi Nakano, Yasuhiro Komatsu, Keiichi Irie, Kohei Suruga, Makoto Yoneyama, Kenichi Mishima, Koichi Matsuo, Kazunari Kadokura
Antimicrobial Coumarins from the Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), from Kenya
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 10
Matthias Heydenreich, Wekesa Neser, Ochieno Dennis, Aggrey Osogo Keya, Korir Cheruiyot Jackson, Kamau R. Wairimu, Juma B. Fredrick, Lilechi D. Baraza