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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i4.20
pages 315-320

Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice

Shafi Mojadadi
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran; and Department of Microbiology & Immunology, School of Medicine, Kerman Medical University, Kerman, Iran
Massoumeh Ebtekar
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran
Zuhair Mohammad Hassan
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran

RESUMO

Ganoderma lucidum (Basidiomycetes) has been recognized as an immunomodulatory natural product. This study was performed in order to investigate the effects of G. lucidum polysaccharide (GL-PS) extract on tumor volume and T(CD4+/CD8+) ratio of tumor infiltrating lymphocytes (TILs) in breast cancer bearing mice. Initially, we performed the DTH (delayed type hypersensitivity) test for obtaining the most effective dose of GL-PS extract on induction of cell-mediated immune response. Then, we evaluated the effect of this dose on tumor volume and CD4+/CD8+ T subpopulations that infiltrated into cancerous breast tissue. Results indicated that GL-PS 100 mg/kg/day could effectively increase DTH response against sRBC in BALB/c mice. Furthermore, intraperitoneal injection of this extract in breast cancer bearing mice could increase T-cell infiltration into the tumor. Also, there was a significant increase in the CD4+/CD8+ ratio in tumor infiltrating lymphocytes as well as a decrease in tumor volume. We concluded that GL-PS can exhibit a potent immunomodulatory effect and may be used for potentiation of the immune system against diseases such as cancer and other conditions in which the immune response has been compromised.


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