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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i4.30
pages 321-328

Water-Soluble Polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) Alleviate the Dose-Limiting Toxicities of Irinotecan (CPT-11)

Zeping Hu
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
Xiao Chen
Department of Clinical Pharmacy, 1st Affiliated Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, China
Xiaoxia Yang
Department of Clinical Pharmacy, 1st Affiliated Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, China
Yihuai Gao
Institute of Food, Nutrition and Human Health, Massey University; Landcare Research, Private Bag 92170, Auckland, New Zealand
Shufeng Zhou
Division of Pharmacy, School of Life Sciences, Faculty of Science, Queensland University of Technology, Australia; Department of Pharmacy, Faculty of Science, National University of Singapore; University of South Florida FL 33612, USA

RESUMO

Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity.


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