Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
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Medicinal Mushroom, Grifola gargal (Agaricomycetes), Lowers Triglyceride in Animal Models of Obesity and Diabetes and in Adults with Prediabetes
RESUMO
Grifola gargal is a medicinal mushroom with biological effects, such as antiatherogenic activity, and is used as a treatment for various chronic inflammatory diseases. The aim of this study is to investigate the antidiabetic and antiobesity effects of a low-molecular weight hot water extract from G. gargal (GGL) against diabetes type 2. In a human clinical trial, 10 subjects with prediabetes consumed 9.2 g of GGL daily for 4 weeks. The significant beneficial health effects observed were decreases in triglyceride levels. This is the first report of these results in humans. Moreover, in animal experiments, we investigated the influence of administered feed with 2% (w/w) GGL for 42 days by using KK-Ay and ob/ob mice as animal models of obesity and diabetes. Results showed that GGL reduces blood glucose and triglyceride levels and adipose tissue. GGL (2.0 mg/mL) significantly suppressed the expression of the cytokine interleukin-6 in 3T3-L1 cells compared with control cells. Thus, the results indicate that G. gargal may be used as a safe and healthy medicinal food to prevent and improve diabetes- and obesity-related metabolic syndrome.
-
Martin KA, Mani MV, Mani A. New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol. 2015;763:64-74.
-
Narayanaswami V, Dwoskin LP. Obesity: current and potential pharmacotherapeutics and targets. Pharmacol Ther. 2017;170:116-47.
-
Fukuda S, Hirata A, Nishizawa H, Nagao H, Kashine S, Kimura T, Inoue K, Fujishima Y, Yamaoka M, Kozawa J, Kitamura T, Yasuda T, Maeda N, Imagawa A, Funahashi T, Shimomura I. Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol. 2015;14:1-8.
-
Wang Z, Nakayama T. Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm. 2010;535918.
-
Casha SW, Beresforda SAA, Henderson JA, McTiernan A, Xiao L, Wang CY, Patrick DL. Dietary and physical activity behaviors related to obesity specific quality of life and work productivity: baseline results from a worksite trial. Br J Nutr. 2012;108(6):1134-42.
-
World Health Organization. Obesity and overweight. 18 October 2017. Available from: http://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 26 May 2018.
-
Deng R. Review of the hypoglycemic effects of five commonly used herbal food supplements. Recent Pat Food Nutr Agric. 2012;4(1):50-60.
-
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H. Discovery and resupply of pharmacologically active plant derived natural products: a review. Biotechnol Adv. 2015;33(8): 1582-1614.
-
Chi Q, Wang G, Sheng Y, Xu W, Shi P, Zhao C, Huang K. Ethanolic extract of the golden oyster mushroom, Pleurotus citrinopileatus (Agaricomycetes), alleviates metabolic syndrome in diet-induced obese mice. Int J Med Mushrooms. 2017;19(11):1001-8.
-
Chien RC, Yang YC, Lai EI, Mau JL. Anti-inflammation and lipogenic inhibition of Taiwanofungus salmonea mycelium and Grifola frondosa fruiting body. Int J Med Mushrooms. 2017;19(7):629-40.
-
Lo H-Ch, Wasser SP. Medicinal mushrooms for glycemic control in diabetes mellitus: history, current status, future perspectives, and unsolved problems (review). Int J Med Mushrooms. 2011;13(5):401-26.
-
Wasser SP. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: a review. Int J Med Mushrooms. 2017;19(4):279-317.
-
Chang ST, Wasser SP. Current and future research trends in agricultural and biomedical applications of medicinal mushrooms and mushroom products (review). Int J Med Mushrooms. 2018;20(12):1121-33.
-
Postemsky PD, Palermo AM, Curvetto NR. Protective effects of new medicinal mushroom, Grifola gargal Singer (higher Basidiomycetes), on induced DNA damage in somatic cells of Drosophila melanogaster. Int J Med Mushrooms. 2011;13(6):583-94.
-
Postemsky P, Curvetto N. Enhancement of wheat grain antioxidant activity by solid state fermentation with Grifola spp. Int J Med Food. 2014;17(5):543-49.
-
Postemsky PD, Curvetto NR. Submerged culture of Grifola gargal and G. sordulenta (higher Basidiomycetes) from Argentina as a source of mycelia with antioxidant activity. Int J Med Mushrooms. 2015;17(1):65-76.
-
Harada E, D'Alessandro-Gabazza CN, Toda M, Morizono T, Totoki T, Yasuma T, Nishihama K, Kobayashi T, Sumiya T, Kawagishi H, Gabazza EC. The medicinal mushroom, Grifola gargal, ameliorates allergic bronchial asthma. Int J Med Food. 2018;21(2):136-45.
-
Harada E, Morizono T, Sumiya T, Megro S. Production of Andean-Patagonic edible mushroom Grifola gargal on wood-based substrates. Mycoscience. 2015;56(6):616-21.
-
Ito T, Kato M, Tsuchida H, Harada E, Niwa T, Osawa T. Ergothioneine as an anti-oxidant/anti-inflammatory component in several edible mushrooms. Food Sci Tech Res. 2011;17:103-10.
-
Harada E, Nagatomi F, Kijidani Y, Meguro S, Kammera T. Utilization of soba-shochu distillery waste for production of benzaldehyde and ergothioneine from liquid culture of the edible basidiomycete Grifola gargal. Mushroom Sci Biotechnol. 2014;21(4):165-71.
-
Asahi T, Wu X, Shimoda H, Hisaka S, Harada E, Kanno T, Nakamura Y, Kato Y, Osawa T. A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation. Biosci Biotechnol Biochem. 2016;80(2):313-17.
-
Wu J, Choi JH, Yoshida M, Hirai H, Harada E, Masuda K, Koyama T, Yazawa K, Noguchi K, Nagasawa K, Kawagishi H. Osteoclast-forming suppressing compounds, gargalols A, B, and C, from the edible mushroom Grifola gargal. Tetrahedron. 2011;67(35):6576-81.
-
Harada E, D'Alessandro-Gabazza CN, Toda M, Morizono T, Chelakkot-Govindalayathil A-L, Roeen Z, Urawa M, Yasuma T, Yano Y, Sumiya T, Gabazza EC. Amelioration of atherosclerosis by the new medicinal mushroom Grifola gargal Singer. J Med Food. 2015;18(8):872-81.
-
Harada E, Morizono T, Sumiya T, Kawagishi H. Effect of the medicinal mushroom, Grifola gargal (Agaricomycetes), on bone turnover markers and serum lipids in middle-aged and elderly Japanese women. Int J Med Mushrooms. 2016;18(1):1-7.
-
Yoshioka Y, Harada E, Ge D, Imai K, Katsuzaki H, Mishima T, Gabazza EC, Ashida H. Adenosine isolated from Grifola gargal promotes glucose uptake via PI3K and AMPK signalling pathways in skeletal muscle cells. J Funct Foods. 2017;33:268-77.
-
Harada E, Morizono T, Saito M. Blood glucose-reducing and fat-reducing effects of a novel medicinal mushroom, Grifola gargal (Agaricomycetes). Int J Med Mushrooms. 2017;19(12):1071-81.
-
Alberts P, Ronquist-Nii Y, Larsson C, Klingstrom G, Engblom L, Edling N, Lidell V, Berg I, Edlund P-O, Ashkzari M, Sahaf N, Norling S, Berggren V, Bergdahl K, Forsgren M, Abrahmsen L. Effect of high-fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-dehydrocorticosterone concentrations. Horm Metab Res. 2005;37(7):402-7.
-
Student AK, Hsu RY, Lane MD. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem. 1980;255:4745-50.
-
World Health Organization. Diabetes. 15 November 2017. Available from: http://www.who.int/en/news-room/fact-sheets/detail/diabetes. Accessed 28 May 2018.
-
Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, Pang G, Cho KY, Song CH. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30(1):49-56.
-
Reza MA, Hossain MA, Damte D, Jo WS, Hsu WH, Park SC. Hypolipidemic and hepatic steatosis preventing activities of the wood ear medicinal mushroom Auricularia auricula-judae (higher Basidiomycetes) ethanol extract in vivo and in vitro. Int J Med Mushrooms. 2015;17(8):723-34.
-
Choi HN, Jang YH, Kim MJ, Seo MJ, Kang BW, Jeong YK, Kim JI. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice. Nutr Res Pract. 2014;8(2):172-76.
-
Seng CK, Abdullah N, Aminudin N. Lipid-modulating effect of black lingzhi medicinal mushroom, Amauroderma rugosum (Agaricomycetes), on oleate-induced human hepatocellular liver carcinoma cells. Int J Med Mushrooms. 2017;19(12):1101-11.
-
Miyazawa N, Yoshimoto H, Kurihara S, Hamaya T, Eguchi F. Improvement of diet-induced obesity by ingestion of mushroom chitosan prepared from Flammulina velutipes. J Oleo Sci. 2018;67(2):245-54.
-
Maschio BH, Gentil BC, Caetano ELA, Rodrigues LS, Laurino LF, Spim SRV, Jozala AF, Dos Santos CA, Grotto D, Gerenutti M. Characterization of the effects of the shiitake culinary-medicinal mushroom, Lentinus edodes (Agaricomycetes), on severe gestational diabetes mellitus in rats. Int J Med Mushrooms. 2017;19(11):991-1000.
-
Zhang J, Zhao X, Zhao LQ, Zhao J, Qi Z, Wang LA. A primary study of the antioxidant, hypoglycemic, hypolipidemic, and antitumor activities of ethanol extract of brown slimecap mushroom, Chroogomphus rutilus (Agaricomycetes). Int J Med Mushrooms. 2017;19(10):905-13.
-
Choi JH, Kim DW, Kim S, Kim SJ. In vitro antioxidant and in vivo hypolipidemic effects of the king oyster culinary-medicinal mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in rats with high-fat diet-induced fatty liver and hyperlipidemia. Int J Med Mushrooms. 2017;19(2):107-19.
-
Paravamsivam P, Heng CK, Malek SN, Sabaratnam V, M RR, Kuppusamy UR. Giant oyster mushroom Pleurotus giganteus (Agaricomycetes) enhances adipocyte differentiation and glucose uptake via activation of PPARy and glucose transporters 1 and 4 in 3T3-L1 cells. Int J Med Mushrooms. 2016;18(9):821-31.
-
Kahles F, Liberman A, Halim C, Rau M, Mollmann J, Mertens RW, Ruckbeil M, Diepolder I, Walla B, Diebold S, Burgmaier M, Lebherz C, Marx N, Lehrke M. The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE/mice by blocking monocyte/macrophage activation. Mol Metab. 2018;14:150-57.
-
Mori K, Ouchi K, Hirasawa N. The anti-inflammatory effects of lion's mane culinary-medicinal mushroom, Hericium erinaceus (higher Basidiomycetes) in a coculture system of 3T3-L1 adipocytes and RAW264 macrophages. Int J Med Mushrooms. 2015;17(7):609-18.
-
Niwa T, Yokoyama S, Ito T, Osawa T. Reduction of leptin secretion by soy isoflavonoids in murine adipocytes in vitro. Phytochem Lett. 2010;3:122-25.
-
Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem. 2003;278(46):45777-84.
-
Chien RC, Lin LM, Chang YH, Lin YC, Wu PH, Asatiani MD, Wasser SG, Krakhmalnyi M, Agbarya A, Wasser SP, Mau JL. Anti-inflammation properties of fruiting bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. Int J Med Mushrooms. 2016;18(11):999-1009.
-
Chowdhury Pritha, Paul Santanu, The Potential Role of Mushrooms in The Prevention and Treatment of Diabetes: A Review, Journal of Biologically Active Products from Nature, 10, 5, 2020. Crossref
-
Ji Xiuyu, Liu Xinli, Zhu Deqiang, Xu Zhenshang, Chu Yaqi, Zhang Song, Grifola Frondosa Polysaccharides affects gut microbiota and lipid profiles depended on the molecular weight in mice, 2021 International Conference on Information Technology and Biomedical Engineering (ICITBE), 2021. Crossref
-
Mustafa Faheem, Chopra Hitesh, Baig Atif Amin, Avula Satya Kumar, Kumari Sony, Mohanta Tapan Kumar, Saravanan Muthupandian, Mishra Awdhesh Kumar, Sharma Nanaocha, Mohanta Yugal Kishore, Edible Mushrooms as Novel Myco-Therapeutics: Effects on Lipid Level, Obesity and BMI, Journal of Fungi, 8, 2, 2022. Crossref