RT Journal Article
ID 01695e29102bf7c5
A1 Sasek, Vaclav
T1 Antibiotic Mucidin from the Porcelain Mushroom Oudemansiella mucida versus Strobilurin from Strobilurus tenacellus (Agaricomycetes)
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2016
FD 2016-09-01
VO 18
IS 6
SP 533
OP 537
K1 Agaricomycetes
K1 antifungal antibiotic
K1 fungicide
K1 higher Basidiomycetes
K1 medicinal mushrooms
K1 Mucidermin Spofa
K1 mucidin
K1 patent protection
K1 strobilurin A
K1 submerged cultivation
AB The antifungal antibiotic mucidin was discovered in the 1960s at the Institute of Microbiology, Prague, Czech Republic, from a submerged culture of the higher Basidiomycetes porcelain mushroom Oudemansiella mucida. Both the production and isolation of mucidin were patented in 1970. Since the patent applications were submitted in 1965 and 1967, respectively, the first disclosed information on mucidin production appeared in 1969 and the mucidin structure was reported in 1979. A series of publications appeared in 1974, covering various aspects of mucidin: mode of action, antifungal spectrum, its effectiveness compared with other antibiotics, and its ability to induce morphological changes in both filamentous fungi and yeasts. Nevertheless, in 1977, German scientists described the antibiotic strobilurin A, which is identical to mucidin, and ignored the existence of mucidin. Strobilurin and its derivatives soon became well known because of their potential as powerful fungicides. The goal of this article is to document the priority of mucidin over strobilurin.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,1e217131685b463b,01695e29102bf7c5.html