%0 Journal Article %A Dave, Vibhuti P. %D 2011 %I Begell House %K pre-TCR, TCR, CD3, T-cell development %N 1 %P 73-84 %R 10.1615/CritRevImmunol.v31.i1.70 %T Role of CD3ε-Mediated Signaling in T-Cell Development and Function %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e645e2f1f194b46,025cd18a7ccbdb1b.html %V 31 %X Receptor-mediated signal transduction plays an important role in T-cell differentiation and function. The pre-T-cell receptor (pre-TCR) and TCR complexes are the most critical receptors for T-cell biology. Signals induced by pre-TCR and TCR in a ligand-independent or a ligand-dependent manner, respectively, are essential for thymocyte maturation. CD3 proteins, which are γ, δ, ε, and ζ polypeptides, play pivotal role in intracellular assembly, surface expression, and signal transduction via the pre-TCR and TCR complexes. Recent studies have suggested central and multiple roles for CD3ε in T-cell development and function. We review the role of the CD3ε chain in T-cell biology. %8 2011-03-10