RT Journal Article ID 09dd601069646892 A1 Vastrik, Imre A1 Makela, Tomi P. A1 Koskinen, Paivi J. A1 Klefstrom, Juha A1 Alitalo, Kari T1 Myc Protein: Partners and Antagonists JF Critical Reviews™ in Oncogenesis JO CRO YR 1994 FD 1994-02-20 VO 5 IS 1 SP 59 OP 68 K1 transformation K1 transcription factor K1 Max K1 Mad K1 Mxi 1 AB One of the first oncogenes identified from human tumors was c-myc, which is frequently activated in Burkitt's lymphomas due to chromosomal translocations. Subsequently, members of the myc oncogene family were found to be amplified in neuroblastoma and small-cell lung cancer. In normal cells, Myc activity has been shown to be both necessary and sufficient for resting cells to enter the cell cycle. Interestingly, it appears that Myc not only drives the cell cycle, but also induces cell death by apoptosis in certain situations. Myc contains a transcriptional activation domain and a basic helix-loop-helix-leucine zipper DNA-binding and dimerization domain. As a heterodimer with a structurally related protein, Max, Myc can bind DNA in a sequence-specific manner. These results suggest that the Myc/Max heterodimer functions as a transcriptional activator of genes that are critical for the regulation of cell growth. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,1241e75b759e4a2a,09dd601069646892.html