RT Journal Article
ID 0e2c5b5e2e8da1f2
A1 Chakraborty, Amrita
A1 Dhar, Pubali
T1 A Review on Potential of Proteins as an Excipient for Developing a Nano-Carrier Delivery System
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2017
FD 2017-12-06
VO 34
IS 5
SP 453
OP 488
K1 protein
K1 nano-vehicle
K1 biocompatibility
K1 biodegradability
K1 bioavailability
K1 bioactivity
K1 uptake mechanism
AB In neo-age research, nano-materials have emerged as potential tools for the revolution of diagnostic and therapeutic field because of their nano-scale effects, increased surface area–volume ratio, and other beneficial properties. For the last few decades, protein has been regarded as the most attractive and versatile natural bio-macromolecule among all of the available biopolymers. Protein is largely exploited as a nano-carrier system in the pharmaceutical industry due to its low cytotoxocity, biocompatibility, biodegradability, abundant renewable sources, significant attaching ability, clinically useful targeting, and site-specific efficient uptake. This review mainly emphasizes on the latest development and progress
achieved in the utilization of protein as a nano-vehicle for a large number of therapeutics such as drugs, genes, hormones, enzymse, nutraceuticals, antibodies, peptides, etc. We also discuss the sources of protein materials, fabrication aspects, advantages, constraints, in vivo
and in vitro studies and provide a comparative analysis between the different types of proteins
as nano-carriers. The variation of the release pattern and molecular mechanism of the encapsulated molecule with respect to different protein types and various nano-structures are also highlighted here to explore the enormous promises of this novel approach.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,53e1c2050d21a805,0e2c5b5e2e8da1f2.html