RT Journal Article ID 128cc2e8493067bf A1 Song, Ying A1 Xiao, Yan A1 Wang, Jia-Ming A1 Chen, Qi T1 The Different Molecular Mechanisms of Mitophagy Between Yeast and Mammals JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2014 FD 2014-02-19 VO 24 IS 1 SP 29 OP 38 K1 Mitochondria K1 autophagy K1 mitophagy K1 Parkinson's disease K1 tumor K1 yeast K1 mammal AB The mitochondrion is the site of energy metabolism inside the cell; which produces ATP for vital activities. The accumulation of damaged mitochondria affects cell survival, these organelles are removed via mitophagy to maintain cell vitality. Currently, mitophagy is a hot topic in life science research. Understanding the role of mitophagy in pathogenesis and its association with the genesis of disease is important for developing treatments for many human diseases. Here, we summarize current progress in the study of mitophagy and describe the different molecular mechanisms of mitophagy between yeast and mammals, as well as related diseases. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,75feda1245856cd3,128cc2e8493067bf.html