RT Journal Article ID 15426d0942b82d2e A1 Hansen, Robert (Trey) A1 Choi, Gene A1 Bryk, Eli A1 Vigorita, Vincent J. T1 The Human Knee Meniscus: A Review with Special Focus on the Collagen Meniscal Implant JF Journal of Long-Term Effects of Medical Implants JO JLT YR 2011 FD 2012-05-09 VO 21 IS 4 SP 321 OP 337 K1 Meniscus implant K1 collagen meniscal implant K1 meniscus K1 tissue engineering K1 meniscus transplant AB The human knee meniscus is important for the protection of the knee joint from degeneration. Because it is so commonly injured, several methods have been developed to replace damaged meniscal tissue with either transplanted menisci or other synthetic implants. Here we review these different approaches, with a clinical and histological focus on the collagen meniscal implant (CMI or Menaflex), a tissue-engineered bovine collagen product. Clinical trials in patients receiving the CMI have demonstrated good clinical outcomes in follow-ups as long as 10 years. We review the findings of second-look biopsies of implanted CMI constructs; they demonstrate the fibrochondrocytic ingrowth of tissue mimicking a native meniscus. Integration of the CMI to host meniscus is also confirmed. The histologic inflammation occasionally observed around the graft appears to be of little clinical significance. We conclude that tissue-engineered menisci from bovine collagen are safe in the time period examined and that they hold promise for future repair of the meniscus in appropriate individuals. PB Begell House LK https://www.dl.begellhouse.com/journals/1bef42082d7a0fdf,0a72446107e87de8,15426d0942b82d2e.html