%0 Journal Article %A Marzvanyan, Anna %A Chen, Vicky %A Zhang, Boshi %A Asatrian, Greg %D 2018 %I Begell House %K herbal medicine, reactive oxygen species, autophagy, apoptosis %N 5-6 %P 333-346 %R 10.1615/CritRevOncog.2018027408 %T Herbal Medicine in the Mitigation of Reactive Oxygen Species, Autophagy, and Cancer: A Review %U https://www.dl.begellhouse.com/journals/439f422d0783386a,476e36ec08ff2fcf,156e66071ed4ca96.html %V 23 %X Since the discovery of autophagy in the mid-2000s, the interest in autophagy-related processes within the scientific community has been burgeoning. Countless authors have investigated its function in cellular homeostasis, but arguably of higher importance is its role during pathology. Although primarily a catabolic process, in cancer cells autophagy has numerous downstream effects, being observed to be both pro- and anti-apoptotic. One of the primary factors mediating this differential role of autophagy is the accumulation or sequestration of reactive oxygen species (ROS). Until recently, despite its increasing popularity in the Western world, the efficacy of herbal supplements has been largely anecdotal. Herein, we reviewed the ten most commonly studied herbs in cancer research and their impact on ROS regulation, on the activation and inhibition of autophagy, and ultimately on cancer cell death. %8 2018-09-26