RT Journal Article
ID 22589d00082034bf
A1 Yoon, Ki Nam
A1 Alam, Nuhu
A1 Shim, Mi Ja
A1 Lee, Tae Soo
T1 Hypolipidemic and Antiatherogenesis Effect of Culinary-Medicinal Pink Oyster Mushroom, Pleurotus salmoneostramineus L. Vass. (Higher Basidiomycetes), in Hypercholesterolemic Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2012
FD 2012-02-10
VO 14
IS 1
SP 27
OP 36
K1 medicinal mushrooms
K1 agarose gel electrophoresis
K1 atherogenic lipid profile
K1 histopathology
K1 hypercholesterolemic rats
K1 hypolipidemic
K1 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
K1 Pleurotus salmoneostramineus
AB The present study was conducted to investigate dietary supplementation of Pleurotus salmoneostramineus fruiting bodies on biochemical and histological effects in hyper- and normocholesterolemic rats. Six-week-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding of diet containing a 5% powder of the fruiting bodies of P. salmoneostramineus in hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and LDL/HDL ratio by 22.55, 51.38, 69.23, 29.67, 16.61, and 65.31%, respectively. The mushroom also significantly reduced body weight in hypercholesterolemic rats. Moreover, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinine, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, and enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. salmoneostramineus significantly reduced plasma β and pre-β-lipoprotein, while it increased α-lipoprotein. A histological study of liver tissues by conventional hematoxylin-eosin and oil red O staining showed normal in mushroom feed hypercholesterolemic rat. This study suggests that the P. salmoneostramineus diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6ea99e900554f74c,22589d00082034bf.html