RT Journal Article
ID 2445230a30cff4d3
A1 Zheng, J.
A1 Hewage, S.R.K. Madduma
A1 Piao, Mei Jing
A1 Kang, Kyoung Ah
A1 Han, X
A1 Kang, H.K.
A1 Yoo, E.S.
A1 Koh, Y.S.
A1 Lee, N.H.
A1 Ko, C. S.
A1 Lee, J. C.
A1 Ko, Mi Hee
A1 Hyuna, Jin Won
T1 Photoprotective Effect of Carpomitra costata Extract against Ultraviolet B-Induced Oxidative Damage in Human Keratinocytes
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2016
FD 2016-04-18
VO 35
IS 1
SP 11
OP 28
K1 reactive oxygen species
K1 oxidative stress
K1 mitochondrial apoptotic pathway
K1 antioxidant enzymes
K1 Carpomitra costata
AB Natural marine products show various biological properties such as antiphotoaging, antioxidant, anticancer, and anti-inflammation. This study evaluated the protective effects of the brown alga Carpomitra costata (Stackhouse) Batters (Sporochnaceae) against ultraviolet B (UVB)-provoked damage in human HaCaT keratinocytes. C. costata extract (CCE) effectively reduced superoxide anion, hydroxyl radical, and UVB-stimulated intracellular reactive oxygen species (ROS) levels. CCE also restored the expression and activity of UVB-suppressed antioxidant enzymes. Furthermore, CCE decreased UVB-triggered oxidative damage to cellular components including DNA, protein, and lipid and defended the cells against mitochondrial membrane depolarization-medicated apoptosis. The results of this study indicate that CCE can safeguard human keratinocytes against UVB-induced cellular damage via a potent antioxidant mechanism. CCE may find utility as part of a therapeutic arsenal against the damaging effects of UVB radiation on the skin.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,051edad754b9dbac,2445230a30cff4d3.html