RT Journal Article ID 2445230a30cff4d3 A1 Zheng, J. A1 Hewage, S.R.K. Madduma A1 Piao, Mei Jing A1 Kang, Kyoung Ah A1 Han, X A1 Kang, H.K. A1 Yoo, E.S. A1 Koh, Y.S. A1 Lee, N.H. A1 Ko, C. S. A1 Lee, J. C. A1 Ko, Mi Hee A1 Hyuna, Jin Won T1 Photoprotective Effect of Carpomitra costata Extract against Ultraviolet B-Induced Oxidative Damage in Human Keratinocytes JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2016 FD 2016-04-18 VO 35 IS 1 SP 11 OP 28 K1 reactive oxygen species K1 oxidative stress K1 mitochondrial apoptotic pathway K1 antioxidant enzymes K1 Carpomitra costata AB Natural marine products show various biological properties such as antiphotoaging, antioxidant, anticancer, and anti-inflammation. This study evaluated the protective effects of the brown alga Carpomitra costata (Stackhouse) Batters (Sporochnaceae) against ultraviolet B (UVB)-provoked damage in human HaCaT keratinocytes. C. costata extract (CCE) effectively reduced superoxide anion, hydroxyl radical, and UVB-stimulated intracellular reactive oxygen species (ROS) levels. CCE also restored the expression and activity of UVB-suppressed antioxidant enzymes. Furthermore, CCE decreased UVB-triggered oxidative damage to cellular components including DNA, protein, and lipid and defended the cells against mitochondrial membrane depolarization-medicated apoptosis. The results of this study indicate that CCE can safeguard human keratinocytes against UVB-induced cellular damage via a potent antioxidant mechanism. CCE may find utility as part of a therapeutic arsenal against the damaging effects of UVB radiation on the skin. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,051edad754b9dbac,2445230a30cff4d3.html