RT Journal Article
ID 2a57853954c058ec
A1 YamaƧ, Mustafa
A1 Kanbak, Gungor
A1 Zeytinoglu, Melih
A1 Senturk, Hakan
A1 Bayramoglu, Gokhan
A1 Dokumacioglu, Ali
A1 Van Griensven, Leonardus Johannes Lambertus Donatus
T1 Pancreas Protective Effect of Button Mushroom Agaricus bisporus (J.E. Lange) Imbach (Agaricomycetidae) Extract on Rats with Streptozotocin-Induced Dia betes
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2010
FD 2011-02-04
VO 12
IS 4
SP 379
OP 389
K1 medicinal mushrooms
K1 Agaricus bisporus
K1 diabetes
K1 hot water extract
K1 hypoglycemic effect
K1 pancreas histology
K1 streptozotocin
AB In the present study we describe the effects of hot water extract of the culinary-medicinal button mushroom, Agaricus bisporus, on the symptoms of streptozotocin-induced diabetes in Sprague Dawley rats. A. bisporus extract at the doses of 0, 100, 200, and 400 mg/kg body weight (bw) per day were orally applied to streptozotocin-induced diabetic rats for a period of 7 days after the onset of the diabetes. Food and water intake and body weight were recorded daily. Upon sacrifice, histological studies were performed on pancreas tissues, and biochemical parameters such as glucose, insulin superoxide dismutase, malondialdehyde and catalase were measured of all experimental groups. The serum glucose levels significantly decreased after oral administration at the dose of 400 mg/kg bw per day by 29.68% with A. bisporus extract. Furthermore, the serum insulin levels in the streptozotocin-induced diabetic rats were increased to 78.50% at the extract dose of 400 mg/kg bw per day. Also, catalase activities and malondialdehyde levels decreased to values slightly above the normal animal control. The most obvious and surprising change was, however, the increase in cellularity of the Langerhans islets of the pancreas and their apparent repopulation with beta cells. We conclude that the oral application of high doses of A. bisporus extract may result in decreased severity of streptozotocin-induced diabetes in rat.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,0ca529c41b1c961c,2a57853954c058ec.html