RT Journal Article ID 2e7329af6c50126d A1 Hu, Zeping A1 Chen, Xiao A1 Yang, Xiaoxia A1 Gao, Yihuai A1 Zhou, Shufeng T1 Water-Soluble Polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) Alleviate the Dose-Limiting Toxicities of Irinotecan (CPT-11) JF International Journal of Medicinal Mushrooms JO IJM YR 2006 FD 2007-01-05 VO 8 IS 4 SP 321 OP 328 AB Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7c3e0ba845ba8869,2e7329af6c50126d.html