RT Journal Article ID 31d7235c0e77631b A1 Maurya, Dharmendra Kumar A1 Ayuzawa, Rie A1 Doi, Chiyo A1 Troyer, Deryl A1 Tamura, Masaaki T1 Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2011 FD 2011-06-01 VO 30 IS 1 SP 1 OP 10 K1 SN-38; adenocarcinoma; apoptosis; mitochondrial membrane potential; cell cycle arrest AB The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and -independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle, and induced apoptosis via activation of caspase 3 and PARP. A single injection of 2mg/kg body weight of SN-38 caused a significant reduction of lung cancer xenografts. These findings indicate that SN-38 induces apoptosis in the lung cancer cells effectively. Thus, SN-38 can potentially be an effective therapeutic agent against lung cancer. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,391ee7667f98e533,31d7235c0e77631b.html