RT Journal Article ID 3e01a56d020baa53 A1 Chen, Jianfeng A1 Sun, Ningjie A1 Hu, Gang A1 Chen, Xiansheng A1 Jiang, Jiansong A1 Wu, Haiming A1 Luo, Gaojian T1 Association of ERCC1 Polymorphisms with the Risk of Colorectal Cancer: A Meta-Analysis JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2017 FD 2017-09-29 VO 27 IS 3 SP 267 OP 275 K1 CRC K1 ERCC1 K1 meta-analysis K1 polymorphism AB The ERCC1 enzyme in the nucleotide excision repair (NER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between ERCC1 polymorphisms and the risk of colorectal cancer (CRC), with conflicting results. To evaluate the potential associations, we conducted a meta-analysis. Eligible studies were identified by searching electronic databases. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the associations between ERCC1 polymorphisms and CRC risk. The meta-analysis results revealed significant associations between ERCC1 rs3212986 and rs2298881 polymorphisms and CRC risk (rs3212986 GG vs CC: OR = 1.66, 95% CI = 1.13–2.44; CG vs CC: OR = 1.12, 95% CI = 0.82–1.55; the dominant model: OR = 1.21, 95% CI = 0.86–1.71; the recessive model: OR = 1.59, 95% CI = 1.09–2.31; rs2298881 CC vs. AA: OR = 2.04, 95% CI = 1.29–3.23; AC vs. AA: OR = 1.19, 95% CI = 0.91–1.56; the dominant model: OR = 1.33, 95% CI = 1.04–1.72; the recessive model: OR = 1.91, 95% CI = 1.22–3.00). However, no association with CRC risk was identified for ERCC1 polymorphisms rs11615 and rs2276466. In conclusion, these findings identified no association between rs11615 and rs2276466 polymorphisms and CRC susceptibility, but the data indicate that ERCC1 rs3212986 and rs2298881 polymorphisms may increase susceptibility to CRC. Large and well-designed studies are needed to further validate our findings. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,3e1db9ff199ae23c,3e01a56d020baa53.html