RT Journal Article
ID 466d0fd13384550d
A1 Wang, Bin 
A1 Gupta, Gaurav
A1 Singh, Mahaveer 
A1 Veerabhadrappa, Kasturi Vishwanatha Setty 
A1 Mishra, Anurag
A1 Chinnaboina, Gopala Krishna 
T1 Pharmacological Evaluation of Novel Flavone from <i>Morus alba</i> in Pentylenetetrazole-Induced Kindling and Oxidative Stress
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2018
FD 2018-03-28
VO 37
IS 1
SP 43
OP 52
K1 <i>Morus alba</i>
K1 isolation
K1 characterization
K1 morusflavone
K1 kindling
K1 oxidative stress
AB The present study was designed to explore the effect of chronic administration of a new flavone &#91;morusflavone, 5,7,4’-trihydroxy-8-(&gamma;,&gamma;-dimethylallyl)-2’,3’-(10’-hydroxy-9’,10’-dimethyl-cyclohex-8-enyl)-flavone (compound 1)&#93; at doses of 25, 50, and 100 mg/kg, orally (p.o.) to pentylenetetrazole-induced kindling in rats (a model of human epilepsy). Compound 1 and four other compounds were isolated from the stem bark of <i>Morus alba</i>. The structure of compound 1 was elucidated and established using standard spectroscopic techniques, and malondialdehyde (MDA) and glutathione (GSH) were estimated as oxidative markers in brain tissues of rodents. The progression of kindling in rats was effectively and significantly suppressed at doses of 25, 50, and 100 mg/kg of compound 1. In addition, increased the levels of MDA and decreased levels of glutathione were also reversed by compound 1 in kindled rats. Compound 1 treatment was able to restore the reduced glutathione level in the brain tissues of PTZ-kindled rats, thus proving its neuroprotective potential.

PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,587b6adf260d3014,466d0fd13384550d.html