RT Journal Article
ID 46704e71491bd63f
A1 Maschio, Bianca Hessel
A1 Gentil, Bianca Carvalho
A1 Caetano, Erika Leão Ajala
A1 Rodrigues, Lucas Silva
A1 Laurino, Leticia Favara
A1 Spim, Sara Rosicler Vieira
A1 Jozala, Angela Faustino
A1 dos Santos, Carolina Alves
A1 Grotto, Denise
A1 Gerenutti, Marli
T1 Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-12-26
VO 19
IS 11
SP 991
OP 1000
K1 food safety
K1 gestational diabetes mellitus
K1 Lentinus edodes
K1 medicinal mushrooms
K1 reproductive toxicology
AB This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational
diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of
gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout
the evolution of pregnancy.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3e829fa15c9a53be,46704e71491bd63f.html