RT Journal Article
ID 477a46d57c048b8e
A1 Lara-Guerra, Humberto  
A1 Roth, Jack A. 
T1 Gene Therapy for Lung Cancer
JF Critical Reviews™ in Oncogenesis
JO CRO
YR 2016
FD 2016-06-28
VO 21
IS 1-2
SP 115
OP 124
K1 lung cancer
K1 gene therapy
AB Gene therapy was originally conceived to treat monogenic diseases. The replacement of a defective gene with a functional gene can theoretically cure the disease. In cancer, multiple genetic defects are present and the molecular profile changes during the course of the disease, making the replacement of all defective genes impossible. To overcome these difficulties, various gene therapy strategies have been adopted, including immune stimulation, transfer of suicide genes, inhibition of driver oncogenes, replacement of tumor-suppressor genes that could mediate apoptosis or anti-angiogenesis, and transfer of genes that enhance conventional treatments such as radiotherapy and chemotherapy. Some of these strategies have been tested successfully in non-small-cell lung cancer patients and the results of laboratory studies and clinical trials are reviewed herein.
PB Begell House
LK https://www.dl.begellhouse.com/journals/439f422d0783386a,3930394d2ef2dece,477a46d57c048b8e.html