RT Journal Article ID 4923aec130567690 A1 Peleg, Sara T1 Responsiveness of Osteoblastic and Osteolytic Bone Metastases to Vitamin D Analogs JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2007 FD 2007-05-21 VO 17 IS 2 SP 149 OP 158 AB Bone is the primary site of metastases in advanced androgen-independent prostate cancer. These metastases are primarily bone-forming, although the presence of osteolytic response has also been reported. Bone-homing therapy is a strategy based on the popular seed-and-soil relationship between the epithelial malignant cells and the bone stroma. Calcitriol (1,25-dihydroxyvitamin D3) and its synthetic analogs (deltanoids) are drugs that have a direct effect on both the skeleton and the invading metastatic cells and, therefore, are considered useful in the treatment of advanced prostate cancer. In this article, I review the nature of the response induced by the malignant cells in the bone (bone formation or bone resorption) and how it affects the outcome of a vitamin D analog treatment in preclinical models of metastatic bone disease. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,31c5e2d111e631ad,4923aec130567690.html