RT Journal Article
ID 4e14c4e165f20b4a
A1 Lee, Li-Ya 
A1 Li, I-Chen 
A1 Chen, Wan-Ping 
A1 Tsai, Yueh-Ting 
A1 Chen, Chin-Chu
A1 Tung, Kwong-Chung 
T1 Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, <i>Hericium erinaceus</i> (Agaricomycetes), Mycelia in Sprague-Dawley Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2019
FD 2019-04-11
VO 21
IS 4
SP 401
OP 411
K1 erinacine A-enriched <i>Hericium erinaceus</i> mycelia
K1 13-week subchronic rodent feeding study
K1 safety,
 neurodegenerative disease
K1 medicinal mushrooms 
AB Recently, erinacine A-enriched <i>Hericium erinaceus</i> (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Following 13 weeks of EAHE mycelia feeding at dosages of 0, 875, 1750, and 2625 mg/kg body weight in both male and female Sprague-Dawley rats, findings revealed neither any mortalities nor noticeable toxicological effects in all the rats during the investigation period. Physiological parameters including body weight and feed consumption patterns were unaffected by EAHE mycelia administration. The hematological and biochemical parameters as well as histopathological studies revealed no significant differences between the treatment and control groups. Conclusively, the obtained results suggested that EAHE mycelia could be relatively unharmful when used over an extended period, supporting its safe use in food preparation.

PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2b9ba90674ebcc50,4e14c4e165f20b4a.html