%0 Journal Article %A Kataoka, Takao %D 2005 %I Begell House %N 1 %P 31-58 %R 10.1615/CritRevImmunol.v25.i1.30 %T The Caspase-8 Modulator c-FLIP %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,7e13a32e4007ec2b,4e2b24983513e512.html %V 25 %X Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors. As an important modulator of caspase-8, c-FLIP regulates life and death in various types of normal cells and tissues, such as lymphoid cells, and renders resistance to death receptor-mediated apoptosis in many types of cancer cells. In addition to an apoptosis modulator, c-FLIP has been shown to exert other physiological functions related to cell proliferation and tumorigenesis. Dysregulation of c-FLIP expression has been shown to be associated with various diseases, such as cancer and autoimmune diseases, and c-FLIP might be a critical target for therapeutic intervention. This review focuses on recent findings about the physiological function and intracellular regulation of c-FLIP. %8 2005-03-28