RT Journal Article
ID 50df170b2f2dbb0c
A1 Goel, Harish Chandra
A1 Bala, Madhu
T1 Radioprotective Effect of Podophyllotoxin in <i>Saccharomyces cerevisiae</i>
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2004
FD 2004-06-08
VO 23
IS 2
OP 6
AB Recent reports showed that whole extract of <i>Podophyllum hexandrum</i> was radioprotective in mice. <sup>1</sup> Podophyllotoxin is one of the major constituents of the whole extract of <i>Podophyllum</i>. In this study we report on the radioprotective action of podophyllotoxin in <i>Saccharomyces cerevisiae</i> yeast. Proliferating yeast cells pretreated with podophyllotoxin (2.5-5.0 &mu;g/mL) for &#8805;3 hours showed a higher surviving fraction after <sup>60</sup>Co-&gamma;-irradiation (200-600 Gy) than did the irradiated cells not pretreated with podophyllotoxin. The maximum increase (2.0 times) in surviving fraction was observed in cells treated with 2.5 &mu;g/mL podophyllotoxin, 5 hours before <sup>60</sup>Co-&gamma;-irradiation (400 Gy). Podophyllotoxin was not mutagenic or recombinogenic at radioprotective doses (2.5 &mu;g/mL). A post-irradiation decrease in revertants and gene convertants was observed in cells treated with podophyllotoxin (2.5 &mu;g/mL podophyllotoxin, -5 hours, 400 Gy). This study indicates that podophyllotoxin is radioprotective in yeast, and its radioprotective effects in higher eukaryotes would be worth investigating.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,69988c136ea159a9,50df170b2f2dbb0c.html