RT Journal Article ID 59eed0792fd49e4c A1 Stabellini, Giordano A1 Calastrini, Carla A1 Marcucci, Anna A1 De Mattei, Monica A1 Luna-Carbonel, Maria I. A1 Pellati, Agnese A1 Mariani, Giustiniano A1 Franchella, Andrea T1 Tissue Expander: Histological and Histochemical Study 6 Months After Transplant—Our Experience JF Journal of Long-Term Effects of Medical Implants JO JLT YR 2000 FD 2000-12-01 VO 10 IS 4 OP 12 AB Implanting an expander in the subcutaneous layer causes gradual expansion and provides additional tissue for reconstruction of tissular defects. The force applied remodels the connective tissue and modifies dermis contractibility in additional tissue. Other authors confirm that parameters such as mitosis and hyaluronan influence the system in the tissue regeneration processes.8,9 We studied histochemical and morphological variations of tissue expanders before and 6 months after transplant. Our histochemical data do not show any changes in dermis glycosaminoglycans of the expanded and transplant-expanded skin when compared to controls. Morphological data demonstrate reorganization of connective fibers and disappearance of the papillar layer. The latter is not yet formed in the expanded skin 6 months after transplant. This suggests that a long time is required for biological reconstruction of epidermal-dermal interactions after transplant. PB Begell House LK https://www.dl.begellhouse.com/journals/1bef42082d7a0fdf,258ad975056e0dd8,59eed0792fd49e4c.html