RT Journal Article ID 5ca2180a7f536d4b A1 Roy, Amrita A1 Das, Avratanu A1 Das, Ruma A1 Haldar, Sagnik A1 Bhattacharya, Sanjib A1 Haldar, Pallab Kanti T1 Naringenin, a Citrus Flavonoid, Ameliorates Arsenic-Induced Toxicity in Swiss Albino Mice JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2014 FD 2014-07-21 VO 33 IS 3 SP 195 OP 204 K1 arsenic toxicity K1 naringenin K1 oxidative stress K1 arsenic trioxide AB In the present study, we evaluated the ameliorative potential of a citrus flavonoid, naringenin (NRG), against experimentally induced arsenic toxicity in Swiss albino mice. NRG (5 and 10 mg kg−l) was administered orally to mice 30 minutes before oral administration of arsenic trioxide (3 mg kg−l) for 14 consecutive days. On day 15, the following parameters were evaluated: body weight; organ weight; hematological profile; serum biochemical profile; hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase levels; and DNA fragmentation. Co-treatment with NRG markedly and significantly normalized body weights, organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters and DNA fragmentation in arsenic-intoxicated mice. The present findings indicate that naringenin remarkably ameliorated the effects of arsenic-induced toxicity in albino mice due to its strong antioxidant property. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,0410fa476f5ceb7e,5ca2180a7f536d4b.html