RT Journal Article
ID 625e19642f0a6409
A1 Tsuchiya, Kohsuke
A1 Hara, Hideki 
T1 The Inflammasome and Its Regulation
JF Critical Reviews™ in Immunology
JO CRI
YR 2014
FD 2014-01-17
VO 34
IS 1
SP 41
OP 80
K1 ASC speck
K1 pyroptosome
K1 NLRP3
K1 caspase-1
K1 mitochondria
K1 nitric oxide
AB Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response to a number of exogenous and endogenous danger signals, leading to the production of pro-inflammatory cytokines and induction of inflammatory cell death through the activation of caspase-1. Inflammasomes have been implicated in a wide range of physiological and pathological processes, including host defense against microbial pathogens, maintenance of intestinal homeostasis, and even development of inflammatory disorders. Thus, inflammasomes can
be both beneficial and detrimental, and understanding the mechanisms involved in inflammasome activation may
provide a better approach to prevent the harmful effects of the inflammatory response. Although inflammasome
complexes are formed via protein-protein interactions between their components, accumulating evidence suggests
that inflammasome activation is positively and negatively regulated by ligand-binding receptors, accessory proteins,
other caspases, cytokines, kinases/phosphatases, redox sensors, ion homeostasis, second messengers, organelles, cytoskeleton, and autophagy, among others. Moreover, inflammasome activation can result in the formation of another caspase-1-activating protein complex, the ASC speck/pyroptosome, which is also tightly controlled. In this review, we discuss how the assembly of inflammasomes and ASC speck is regulated by complex mechanisms. Recent findings
on effector functions and biological roles of inflammasomes also are summarized.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,4841bae138dd5eca,625e19642f0a6409.html