%0 Journal Article %A Liu, Yong %A Ma, Chaoyu %A Zhang, Nu %D 2018 %I Begell House %K CD4, CD8, infection, IL-15, Memory, TGF-beta %N 2 %P 79-103 %R 10.1615/CritRevImmunol.2018025653 %T Tissue-Specific Control of Tissue-Resident Memory T Cells %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,443ae0ff4b5271d1,736f002a687dc8bd.html %V 38 %X Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of TRMs. Here, we discuss recent advances in the TRM field with a special emphasis on the interaction between local signals and TRMs in the context of individual tissue environment. %8 2018-04-26