%0 Journal Article %A Sigvardsson, Mikael %A Liberg, David %D 1999 %I Begell House %N 2 %P 27 %R 10.1615/CritRevImmunol.v19.i2.30 %T Transcriptional Regulation in B Cell Differentiation %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,15afc8eb551e1d16,747b57eb4590a6db.html %V 19 %X B cell development is a multistage differentiation process that ultimately generates antibody-secreting plasma cells. This model developmental pathway is governed by a choreographed pattern of expression from genes encoding stage and lineage-specific proteins. This is achieved by the interaction of distinct transcription factors with regulatory elements, placing these proteins in a central position in B cell ontogeny. The importance of distinct transcription factors is also supported by the notion that B cell development is disrupted in mice bearing homozygous null alleles of certain factors involved in the control of B-cell-specific genes. In this review we compare and contrast the transcriptional regulation of well-studied B lymphoid restricted genes, on a gene by gene basis, focusing on the functional structure of transcription control regions and interacting transcription factors. %8 1999-04-01