RT Journal Article
ID 7577900610abe46e
A1 Nisar, Jaweria
A1 Mustafa, Imtiaz
A1 Anwar, Haseeb
A1 Sohail, Muhammad Umar
A1 Hussain, Ghulam
A1 Ullah, Muhammad Irfan
A1 Faisal, Muhammad Naeem
A1 Bukhari, Shazia Anwer
A1 Basit, Abdul
T1 Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-12-26
VO 19
IS 11
SP 981
OP 990
K1 hepatoprotective
K1 hypercholesterolemia
K1 immunomodulatory
K1 Lentinus edodes
K1 medicinal mushrooms,
oxidative stress
AB Lentinus edodes is a culinary-medicinal mushroom that has an established history of use in Asian therapies. The mushroom offers well-documented beneficial health effects such as antihypercholesterolemic, antitumor, and antibacterial activities. In this study, dried powder of L. edodes fruiting bodies was used to evaluate immunomodulatory,
hepatoprotective, and antioxidant effects in hypercholesterolemic rats. Albino rats (n = 24) were divided into 3 groups: the control (CON) group, the hypercholesterolemia-only group (HCG), and the L. edodes group (LEG). Hypercholesterolemia was induced in rats in the HCG and LEG by feeding cholesterol and cholic acid in a chow
maintenance diet (CMD) for 24 days. The CON group was fed the CMD throughout the experiment. The HCG continued
on the high-cholesterol diet without any L. edodes supplement. The LEG was fed the high-cholesterol diet
supplemented with L. edodes for an additional 42 days. Various biological health biomarkers, such as total antioxidant capacity, total oxidant status, arylesterase, paraoxonase activity, and liver enzymes in serum were studied to evaluate antioxidant and hepatoprotective responses. Cell-mediated immunity was evaluated in each group through a delayed type of hypersensitivity reaction. The total oxidant status decreased significantly (P ≤ 0.05) after administration of L. edodes in the diet. The cell-mediated immune response significantly increased (P ≤ 0.05) in the LEG. The significant decrease in liver enzymes supports the hepatoprotective effect of L. edodes. In conclusion, the results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemic rats.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3e829fa15c9a53be,7577900610abe46e.html