RT Journal Article
ID 791d12846654d6b2
A1 Ashafaq, Mohammad 
A1 Sharma, Pooja 
A1 Khatoon, Saima 
A1 Haque, Dilruba 
A1 Tabassum, Heena
A1 Parvez, Suhel
T1 Heavy Metal−Induced Systemic Dysfunction Attenuated by Tannic Acid
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2016
FD 2016-07-28
VO 35
IS 2
SP 109
OP 120
K1 lead
K1 liver
K1 kidney
K1 rats
K1 toxicity
K1 antioxidant
AB Lead toxicity is a major public health concern. This study was designed to investigate the effects of oral administration of tannic acid (TA) on lead acetate (LA)−induced oxidative stress in rat liver and kidney. Rats were treated with 50 mg/kg body weight of TA against LA-induced oxidative stress 3 times/week for 2 weeks. At a rate of 50 mg/kg of body weight, LA was given intraperitoneally 3 times/week for 2 weeks. Results show significantly elevated levels of oxidative stress markers observed in LA-treated rats, whereas significant depletion in the activity of nonenzymatic and enzymatic antioxidants as well as histological changes were observed in LA-treated rat liver and kidney. TA treatment significantly attenuated the altered levels of oxidative stress biomarkers for nonenzymatic and enzymatic antioxidants. We demonstrated that TA exhibits potent antioxidant and protected against oxidative damage in rat liver and kidney induced by LA treatment. These findings were further supported by histopathological findings in liver and kidney showing that TA protected tissue from the deleterious effects of LA treatment. These outcomes suggest that the consumption of TA may confer a protective effect against lead intoxication through its antioxidative effect.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,791d12846654d6b2.html