Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 40, 2021 Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i2.70
pages 127-133

Photodynamic Treatment of Oral Lesions

Sigrid I. Kvaal
Faculty of Dentistry, University of Oslo, Oslo Norway
Trond Warloe
The Norwegian Radium Hospital, University of Oslo, Oslo, Norway

Краткое описание

Photodynamic treatment (PDT) was first started in the oral cavity in the mid 1980s. Hematoporphyrins were rapidly replaced by Photofrin and meta-tetrahydroxyphenylchlorin (mTHPC) as photosensitisers of choice, and over the years these two have been approved by several health authorities for PDT. 5-aminolevulinic acid (ALA) and some dyes (e.g., toluidine and methyene blue) have also been tested. Several different nonthermal lasers have been used and lately light-emitting diodes (LEDs) have been tried. Most of the clinical treatments have been carried out on oral squamous cell carcinoma (OSSC), either primary or metastatic lesions, with good results. The treatment leaves little scarring and can be used before, in conjunction with, and adjunctive to other treatment modalities. The greatest disadvantage is that the patients are photosensitive for several weeks following systemic administration of the photosensi-tiser. PDT is now an accepted palliative treatment. Systemic administration of ALA has been more successful than local application in the treatment of precancerous lesions such as oral leukoplakia. PDT following topical application of photosensitiser (metylene blue and methyl-ALA) has shown improvement in cutaneous diseases of the oral mucous membrane such as oral lichen planus. The bactericidal effect of PDT has also been tested on oral plaque, but little clinical work has been performed so far. Instead of mechanical cleaning or antibiotic therapy, PDT may also play a role in dental diseases.


Articles with similar content:

Preface: Special Issue of Photodynamic Therapy and Photodetection with Porphyrin Precursors for the Journal of Environmental Pathology, Toxicology, and Oncology
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Alcira Batlle, Qian Peng
New Derivatives of 5-Aminolevulinic Acid for Photodynamic Therapy: Chemical Synthesis and Porphyrin Production in In Vitro and In Vivo Biological Systems
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Aslak Godal, Jahn M. Nesland, Jon Erik Branden, Jo Klaveness, Nils O. Nilsen, Qian Peng
Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Martin J. Garland, Desmond I. J. Morrow, Paul A. McCarron, Ryan F. Donnelly, A. David Woolfson
Role of Block Copolymer Nanoconstructs in Cancer Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 2
H. G. Agrawal, K. K. Upadhyay, C. Schatz, Sebastian Lecommandoux, J. F. Le Meins, Ambikanandan Misra, C. Upadhyay
Improving the Management of Bladder Cancer with Fluorescence Cystoscopy
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
H. Barton Grossman