Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.110
11 pages

Low Doses of Heavy Metals Disrupt Normal Structure and Function of Rat Platelets

Siragam Vinaya Kumar
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India
Rakhi Bose
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India
Shelley Bhattacharya
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India

Краткое описание

Aggregation, an important property of platelets, plays a key role in the coagulation of blood and is potentiated by ADP and adrenaline, whereas cAMP acts as a strong inhibitor. Because of the rise in the heavy metal load in the environment, more studies are necessary to look at its subtle effects in the animal system, wherein platelet structure and function can be targeted. We carried out structural analyses under phase contrast and scanning electronmicroscopy of the platelets prepared from 1/10 LD50 metal-treated rats. After mercury (Hg) and arsenic (As) treatment, the cell margins appeared irregular and wavy, with small pseudopodia-like protrusions from the surface. Cadmium (Cd) treatment caused loss of the general spindle shape, and the platelets assumed a round spongy appearance. All metal treatments effected enhanced collagen-induced aggregation and inhibited ADP and arachidonic acid-induced aggregation, whereas epinephrine accelerated aggregation in Hg and Cd treatment but inhibited aggregation in As treatment. Cd proved a potent inhibitor of phosphodiesterase, increasing the cAMP level in in vitro treatments at equimolar (5, 10, and 20 pmoles) concentrations. The rate of aggregation was enhanced with all the agonists used in in vitro Hg and As treatments, with concomitant reduction in cAMP, while Cd inhibited platelet aggregation. Thus, we can conclude that cytosolic cAMP, which is decreased by the metal-induced inhibition of phosphodiesterase, is a regulator molecule in platelet aggregation. Furthermore, it is also abundantly clear that equimolar doses of metals are not always equitoxic. Therefore, the action of each xenobiotic is not only due to the concentration used but also to the type of xenobiotic depending on its unique mechanism of action.


Articles with similar content:

Cyclooxygenase-2 Inhibition by Etoricoxib Modulates Plasma Membrane Fluidity in Rat Colon
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 4
Sankar Nath Sanyal, Shailender Singh Kanwar, Nancy Behal, Jasmeet Kaur
Role of Zinc in Modulating Histoarchitectural and Biochemical Alterations During Dimethylhydrazine (DMH)-Induced Rat Colon Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 4
Devinder K. Dhawan, Anshoo Malhotra, Vijayta Dani Chadha, Praveen Nair
Photochemical Internalization (PCI): A New Modality for Light Activation of Endocytosed Therapeuticals
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Birgit Engesater, Anette Bonsted, Anette Weyergang, Pal Kristian Selbo, Lina Prasmickaite, Andreas Dietze, Kristian Berg, Anders Hogset
Azo Chemistry and Its Potential for Colonic Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 5
Yashwant Gupta, Anekant Jain, Sanjay Kumar Jain
Protective Effect of Diphenylmethyl Selenocyanate Against Carbon Tetrachloride-Induced Hepatotoxicity In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.23, 2004, issue 4
Rajat Kumar Das, Sudin Bhattacharya, Sukta Das