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Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.80
5 pages

Retrospective Dosimetry Based on Cytogenetic Study of Individuals Chronically Exposed to Ionizing Radiation

Sreedevi Balakrishnan
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, India
Badanidiyoor S. Rao
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, India

Краткое описание

Analysis of chromosomal aberrations (CAA) was carried out in 27 radiation workers with cumulative exposures of approximately 500 mSv received over a period of 2-3 decades. A similar study was carried out in 20 age- and gender-matched healthy individuals who served as controls. The average age of the exposed group was 50 years, and that of the controls was 51 years. The absorbed radiation dose was calculated by using the linear component of the in vitro dose response curve established for 60Co g-rays. In the controls we found only 3 dicentrics in 5,500 metaphases analyzed. In the exposed group, we detected 49 dicentrics and 1 centric ring in 13,900 metaphases analyzed. Because of the small number of dicentrics scored in each individual, the dose estimates of our method of study suffers from a large statistical uncertainty. The collective dose calculated from our data was 3.4 Sv. The difference in the physical dose based on personal monitoring and that from biological dosimetry may be attributed to the disappearance of lymphocytes carrying the aberrations from the living system. These results are consistent with the present knowledge of the kinetics of turnover of T-lymphocytes. Most residual damage appears to be from the longlived component of T-lymphocytes with a mean life of 10 years.


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